DSC2 Protein & Antibody

Desmocollin 2

DSC2 Products

DSC2 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
DSC2	Human	DSC2/Desmocollin-2 Protein, Recombinant	10809-H08H
DSC2	Rat	DSC2 / Desmocollin-2 Protein, Recombinant	80266-R08H

DSC2 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human DSC2	WB, ELISA	DSC2 Antibody	10809-RP01
Human DSC2	WB, ELISA	DSC2 Antibody (Antigen Affinity Purified)	10809-RP02

DSC2 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
DSC2	Human	Homo sapiens DSC2/Desmocollin-2 cDNA Clone	HG10809-M
DSC2	Mouse	Desmocollin-2 cDNA Clone / ORF Clone	MG50401-M
DSC2	Rat	DSC2 cDNA Clone / ORF Clone	RG80266-G

DSC2 Related Areas

Immunology>>Adhesion Molecule>>Cadherin>>DSC2

DSC2 Alternative Names

DSC2, ARVD11, CDHF2, DG2, DGII/III, DKFZp686I11137, DSC3 [Homo sapiens]

Dsc2, AW228162, Dsc2a, Dsc2b [Mus musculus]

DSC2 Background

DSC2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Like other desmocollins, murine DSC2 has two products, Dsc2a and Dsc2b, produced by alternative splicing of a 46 bp exon which encodes 11 COOH-terminal aa followed by an in-frame stop codon. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in DSC2 are associated with arrhythmogenic right ventricular dysplasia-11. DSC2 is Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSC2 may contribute to epidermal cell positioning by mediating differential adhesiveness between cells that express different isoforms.

DSC2 Related Studies

1. Nuber UA, et al. (1995) The widespread human desmocollin Dsc2 and tissue-specific patterns of synthesis of various desmocollin subtypes. Eur J Cell Biol. 66 (1): 69-74.
2. Marsden MD, et al. (1997) Cloning and transcriptional analysis of the promoter of the human type 2 desmocollin gene (DSC2). Gene. 186 (2): 237-47.
3. Greenwood MD, et al. (1997) Exon-intron organization of the human type 2 desmocollin gene (DSC2): desmocollin gene structure is closer to "classical" cadherins than to desmogleins. Genomics. 44 (3): 330-5.