Anti-Desmocollin 2 Antibody

Cat: 10809-RP01
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Anti-Desmocollin 2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Desmocollin 2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Desmocollin 2
Immunogen
Recombinant Human DSC2 protein (Catalog#10809-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human DSC2 (rh DSC2; Catalog#10809-H08H; Q02487-1; Met 1-Arg 684). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Desmocollin 2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Desmocollin 2 Antibody Alternative Names
Anti-ARVD11 Antibody;Anti-CDHF2 Antibody;Anti-DG2 Antibody;Anti-DGII/III Antibody;Anti-DSC3 Antibody
Desmocollin 2 Background Information

DSC2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Like other desmocollins, murine DSC2 has two products, Dsc2a and Dsc2b, produced by alternative splicing of a 46 bp exon which encodes 11 COOH-terminal aa followed by an in-frame stop codon. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in DSC2 are associated with arrhythmogenic right ventricular dysplasia-11. DSC2 is Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSC2 may contribute to epidermal cell positioning by mediating differential adhesiveness between cells that express different isoforms.

Full Name
desmocollin 2
References
  • Nuber UA, et al. (1995) The widespread human desmocollin Dsc2 and tissue-specific patterns of synthesis of various desmocollin subtypes. Eur J Cell Biol. 66 (1): 69-74.
  • Marsden MD, et al. (1997) Cloning and transcriptional analysis of the promoter of the human type 2 desmocollin gene (DSC2). Gene. 186 (2): 237-47.
  • Greenwood MD, et al. (1997) Exon-intron organization of the human type 2 desmocollin gene (DSC2): desmocollin gene structure is closer to "classical" cadherins than to desmogleins. Genomics. 44 (3): 330-5.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Desmocollin 2 Antibody Rabbit Polyclonal ELISA 80266-RP01
    Anti-Desmocollin 2 Antibody Mouse Monoclonal ELISA 80266-MM05
    Anti-Desmocollin 2 Antibody Rabbit Monoclonal IHC-P 80266-R003
    Anti-Desmocollin 2 Antibody Rabbit Monoclonal ELISA 80266-R023
    Anti-Desmocollin 2 Antibody Rabbit Polyclonal ELISA,IHC-P 80266-T24
    Anti-Desmocollin 2 Antibody Rabbit Polyclonal ELISA,IHC-P 10809-RP02
    Anti-Desmocollin 2 Antibody Mouse Monoclonal ELISA 10809-MM06
    Anti-Desmocollin 2 Antibody Rabbit Monoclonal ELISA 10809-R521
    Anti-Desmocollin 2 Antibody Mouse Monoclonal ELISA 10809-MM04
    Anti-Desmocollin 2 Antibody Rabbit Monoclonal ELISA 10809-R004
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