DPP7 Protein & Antibody (DPPII, DPP2)

Dipeptidyl-peptidase 7 (Dipeptidyl peptidase II)

DPP7 / DPPII / DPP2 Products

DPP7 / DPPII / DPP2 Protein, Recombinant

Molecule	Species	Description	Cat. No
DPP7 / DPPII / DPP2	Human	DPP7 / DPPII / DPP2 Protein, Recombinant (His Tag)	10748-H08H
DPP7 / DPPII / DPP2	Mouse	DPP7 / DPPII / DPP2 Protein, Recombinan (His Tag)	51019-M08H

DPP7 / DPPII / DPP2 Antibody

Molecule	Application	Description	Cat. No
Human DPP7 / DPPII / DPP2	WB	Monoclonal Antibody	10748-MM02
Human DPP7 / DPPII / DPP2	ELISA	Monoclonal Antibody	10748-MM03
Human DPP7 / DPPII / DPP2	ELISA	Polyclonal Antibody	10748-RP01
Human DPP7 / DPPII / DPP2	WB, ELISA	Polyclonal Antibody (Antigen Affinity Purified)	10748-RP04

DPP7 / DPPII / DPP2 cDNA Clone

Molecule	Species	Description	Cat. No
DPP7 / DPPII / DPP2	Human	Human DPP7 / DPPII / DPP2 cDNA Clone / ORF Clone	HG10748-M
DPP7 / DPPII / DPP2	Mouse	Mouse DPP7 / DPPII / DPP2 cDNA Clone / ORF Clone	MG51019-G

DPP7 / DPPII / DPP2 Elisa Pair Set

Molecule	Application	Description	Cat. No
Human DPP7 / DPPII / DPP2	ELISA	DPP7 / DPPII / DPP2 Elisa Pair Set	SEK10748

DPP7 / DPPII / DPP2 Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>DPPIV Family>>DPP7 / DPPII / DPP2

DPP7 / DPPII / DPP2 Alternative Names

DPP7 / DPPII / DPP2, DPPII, DPP2, QPP [Homo sapiens]

DPP7 / DPPII / DPP2, DPPII, Dpp2, QPP, RP23-47P18.2 [Mus musculus]

DPP7 / DPPII / DPP2 Background

DPP7 (dipeptidylpeptidase 7), also known as DPPII and DPP2, is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. Dipeptidyl peptidases (DPPs) have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. It localizes to lysosomes. DPP7 localizes to lysosomes and exists as a homodimer via its leucine zipper motif and is involved in the degradation of oligopeptides. In response to calcium release, it can be secreted in its active form. It is essential for lymphocyte survival, as the inhibition of DPP7 results in quiescent cell apoptosis.

DPP7 / DPPII / DPP2 Related Studies

1. Chiravuri M, et al. (1999) A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. J Immunol. 163(6):3092-9.
2. Fukasawa KM, et al. (2001) Cloning and functional expression of rat kidney dipeptidyl peptidase II. Biochem J. 353(Pt 2):283-90.
3. Fornas E, et al. (1992) Effect of cholesterol and its autooxidation derivatives on endocytosis and dipeptidyl peptidases of aortic endothelial cells. Histol Histopathol. 7(2):163-8.