Anti-DPP2 Antibody

Cat: 10748-RP01
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Anti-DPP2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-DPP2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human DPP2
Immunogen
Human cell-derived rhDPPII (Catalog#10748-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human DPPII (rhDPPII; Catalog#10748-H08H; NP_037511.2, Met 1-Leu 492). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-DPP2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-DPP2 Antibody Alternative Names
Anti-DPP2 Antibody;Anti-DPPII Antibody;Anti-QPP Antibody
DPP2 Background Information

DPP7 (dipeptidylpeptidase 7), also known as DPPII and DPP2, is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. Dipeptidyl peptidases (DPPs) have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. It localizes to lysosomes. DPP7 localizes to lysosomes and exists as a homodimer via its leucine zipper motif and is involved in the degradation of oligopeptides. In response to calcium release, it can be secreted in its active form. It is essential for lymphocyte survival, as the inhibition of DPP7 results in quiescent cell apoptosis.

Full Name
dipeptidyl-peptidase 7
References
  • Chiravuri M, et al. (1999) A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. J Immunol. 163(6):3092-9.
  • Fukasawa KM, et al. (2001) Cloning and functional expression of rat kidney dipeptidyl peptidase II. Biochem J. 353(Pt 2):283-90.
  • Fornas E, et al. (1992) Effect of cholesterol and its autooxidation derivatives on endocytosis and dipeptidyl peptidases of aortic endothelial cells. Histol Histopathol. 7(2):163-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-DPP2 Antibody Rabbit Polyclonal ELISA 51019-T16
    Anti-DPP2 Antibody Rabbit Polyclonal ELISA 51019-RP01
    Anti-DPP2 Antibody Rabbit Monoclonal ELISA 51019-R035
    Anti-DPP2 Antibody Rabbit Polyclonal WB,ELISA 51019-T48
    Anti-DPP2 Antibody Rabbit Monoclonal ELISA 10748-R003
    Anti-DPP2 Antibody Mouse Monoclonal ELISA,ELISA(Cap) 10748-MM05
    Anti-DPP2 Antibody Rabbit Polyclonal ELISA 10748-RP04
    Anti-DPP2 Antibody Mouse Monoclonal ELISA,ELISA(Det) 10748-MM03
    Anti-DPP2 Antibody Rabbit Polyclonal IHC-P 101556-T08
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