|Datasheet||Specific References||Reviews||Related Products||Protocols|
|ORF Clone of Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) dipeptidyl-peptidase 4 DNA.|
|Identical with NM_001032959.1 [ Macaca mulatta (Rhesus monkey) ]: 131 T/C, 544 G/A, 2252 C/T resulting in the amino acid Ile substitution by Thr, Gly substitution by Ser, Thr substitution by Ile and 1086 C/T, 2052 A/G not causing the amino acid variation. Please check the sequence information before order.|
|Whatman FTA elute card (Cat: WB120410) contains 5-10 μg of plasmid.|
|The Whatman FTA elute card can be stored at room temperature for three months under dry condition.|
The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.
The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.
|Cynomolgus monkey DPP4 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged||CG90180-G-F|
|Cynomolgus monkey DPP4 Gene cDNA Clone (full-length ORF Clone), expression ready, His-tagged||CG90180-G-H|
|Cynomolgus monkey DPP4 Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-tagged||CG90180-G-M|
|Cynomolgus monkey DPP4 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged||CG90180-G-N|
|Cynomolgus monkey DPP4 Gene cDNA Clone (full-length ORF Clone), expression ready, HA-tagged||CG90180-G-Y|
|Product name||Product name|
Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). The soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). This causes an increase in glucose-dependent stimulation of insulin secretion, resulting in a lowering of blood glucose levels. Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin (HbA(1c)) levels, either as monotherapy or as a combination with other antidiabetic agents. Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development, and are a new pharmacological class of drugs for treating Type 2 diabetes.