DPP10

DPP10 has no dipeptidyl aminopeptidase activity. DPP10 may modulate cell surface expression and activity of the potassium channels KCND1 and KCND2.

DPP10 Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>DPPIV Family>>DPP10

DPP10 Alternative Names

DPP10, DPL2, DPPY, DPRP3, DPP X, DPRP-3 [Homo sapiens]

Dpp10, 6430601K09Rik, DPP X, Dprp3 [Mus musculus]

Summaries for DPP10

Entrez Gene summary for DPP10:

This DPP10 gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. DPP10 has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, DPP10 does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Wikipedia summary for DPP10:

Inactive dipeptidyl peptidase 10 is a protein that in humans is encoded by the DPP10 gene.

Human DPP10 Protein General Information

 

• Protein names: Inactive dipeptidyl peptidase 10
• Sequence length: 796 AA.
• Sequence similarities: DPP10 belongs to the peptidase S9B family. DPPIV subfamily.
• Post-translational modification: N-glycosylated.
• Subunit structure: DPP10 may form oligomers. DPP10 interacts with KCND1. DPP10 interacts with KCND2.
• Subcellular location: Membrane; Single-pass type II membrane protein
• Tissue specificity: Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.
• Involvement in disease: Genetic variations in DPP10 are associated with susceptibility to asthma (ASTHMA) [MIM:600807]. The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.
• Caution: Gly-651 is present instead of the conserved Ser which is expected to be an active site residue.
• Sequence caution: The sequence BAA96016.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

General information above from UniProt

Function for DPP10 Protein

UniProtKB:

DPP10 has no dipeptidyl aminopeptidase activity. DPP10 may modulate cell surface expression and activity of the potassium channels KCND1 and KCND2.

Genatlas:

• cleaves terminal dipeptides from cytokines and chemokines, and presents a potential new target for asthma therapy

Homology for human DPP10

• ortholog to murine Dpp10
• ortholog to ratus Dpp10_predicted
• homolog to DPP6