Anti-DDC Antibody

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Anti-DDC Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-DDC Antibody
Validated applications
ELISA,ELISA(Det)
Species reactivity
Reacts with: Human
Specificity
Human DDC
Immunogen
Recombinant Human DDC protein (Catalog#10560-H08B)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human DDC / AADC (rh DDC; Catalog#10560-H08B; NP_000781.1; Met 1-Glu 480).
Source
Monoclonal Rabbit IgG Clone #40
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-DDC Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
ELISA 1:5000-1:10000
ELISA(Det) 1:1000-1:10000
Notes
ELISA(Det): This antibody will detect Human DOPA Decarboxylase / DDC in ELISA pair set (Catalog: # SEK10560). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 10560-R003).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-DDC Antibody: Alternative Names

Anti-AADC Antibody

DDC Background Information

Dopa Decarboxylase (DDC), also known as AADC and Aromatic-L-amino acid decarboxylase, is a 54 kDa member of the group II decarboxylase family of proteins.It is a vitamin B6-dependent homodimeric enzyme that catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Since L-DOPA is regularly used to treat the symptoms of Parkinson's disease, the catalytic pathway is of particular research interest. Defects of DDC are associated with severe developmental delay, oculogyric crises (OGC), as well as autosomal recessive disorder AADC deficiency, an early onset inborn error in neurotransmitter metabolism which can lead to catecholamine and serotonin deficiency.
Full Name
dopa decarboxylase (aromatic L-amino acid decarboxylase)
References
  • Ichinose, H. et al.,1989,Biochem. Biophys. Res. Commun. 164: 1024-1030.
  • Lisa, J. S. et al., 1992, Genomics 13: 469-471.
  • Moore, P. S. et al.,1996, Biochem. J. 315:249-256.
  • Bertoldi, M. et al., 2003, Biochim. Biophys. Acta. 1647:42-47.
  • Vassilacopoulou, D. et al., 2004, Neurochem. Res. 29: 1817-1823.
  • Ma, J.Z., et al., 2005, Hum. Mol. Genet. 14: 1691-1698.
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