Anti-DDC Antibody

Cat: 10560-RP01
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Anti-DDC Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-DDC Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human DDC
Immunogen
Recombinant Human DDC protein (Catalog#10560-H08B)
Preparation
Produced in rabbits immunized with purified, recombinant full length of human DDC / AADC (rh DDC; Catalog#10560-H08B; NP_000781.1; Met 1-Glu 480). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-DDC Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-DDC Antibody Alternative Names
Anti-AADC Antibody
DDC Background Information

Dopa Decarboxylase (DDC), also known as AADC and Aromatic-L-amino acid decarboxylase, is a 54 kDa member of the group II decarboxylase family of proteins.It is a vitamin B6-dependent homodimeric enzyme that catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Since L-DOPA is regularly used to treat the symptoms of Parkinson's disease, the catalytic pathway is of particular research interest. Defects of DDC are associated with severe developmental delay, oculogyric crises (OGC), as well as autosomal recessive disorder AADC deficiency, an early onset inborn error in neurotransmitter metabolism which can lead to catecholamine and serotonin deficiency.

Full Name
dopa decarboxylase (aromatic L-amino acid decarboxylase)
References
  • Ichinose, H. et al.,1989,Biochem. Biophys. Res. Commun. 164: 1024-1030.
  • Lisa, J. S. et al., 1992, Genomics 13: 469-471.
  • Moore, P. S. et al.,1996, Biochem. J. 315:249-256.
  • Bertoldi, M. et al., 2003, Biochim. Biophys. Acta. 1647:42-47.
  • Vassilacopoulou, D. et al., 2004, Neurochem. Res. 29: 1817-1823.
  • Ma, J.Z., et al., 2005, Hum. Mol. Genet. 14: 1691-1698.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-DDC Antibody Rabbit Polyclonal WB,ELISA,IHC-P 50799-T56
    Anti-DDC Antibody Rabbit Polyclonal ELISA 50799-RP01
    Anti-DDC Antibody Rabbit Monoclonal ELISA,IHC-P 10560-R005
    Anti-DDC Antibody Rabbit Polyclonal ELISA 10560-RP02
    Anti-DDC Antibody Rabbit Monoclonal ELISA,ELISA(Det) 10560-R040
    Anti-DDC Antibody Mouse Monoclonal ELISA 10560-MM04
    Anti-DDC Antibody Rabbit Monoclonal ELISA(Cap) 10560-R003
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