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DMBT1 / Muclin Antibody, Rabbit PAb, Antigen Affinity Purified

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Human DMBT1/GP340 Antibody Product Information
Immunogen:Recombinant Human DMBT1 protein (Catalog#11678-H08H)
Clone ID:
Ig Type:Rabbit IgG
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human DMBT1 (rh DMBT1; Catalog#11678-H08H; NP_004397.2; Met 1-Ser 220). DMBT1 specific IgG was purified by human DMBT1 affinity chromatography .
Human DMBT1/GP340 Antibody Usage Guide
Specificity:Human DMBT1 / GP340
Application:ELISA, IHC-P

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human DMBT1. The detection limit for Human DMBT1 is approximately 0.00975 ng/well.

IHC-P: 0.1-2 μg/mL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human DMBT1/GP340 Antibody IHC Application Image
[Click to enlarge image]
Immunochemical staining of human DMBT1 in human colon carcinoma with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
DMBT1 / Muclin Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Other DMBT1/GP340 Antibody Products
DMBT1/Muclin Background

Deleted in malignant brain tumors 1 protein, also known as glycoprotein 340, surfactant pulmonary-associated D-binding protein, DMBT1 and GP340, is a secreted protein which belongs to the DMBT1 family. DMBT1 contains 2 CUB domains, 14 SRCR domains and 1 ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are involved in the development of glioma (GLM). Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas , and ependymomas. 

DMBT1 may be considered as a candidate tumor suppressor for brain, lung, esophageal, gastric, and colorectal cancers. It may play roles in mucosal defense system, cellular immune defense and epithelial differentiation. DMBT1 may play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. It may be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. DMBT1 may function as a binding protein in saliva for the regulation of taste sensation. It binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission.

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Catalog: 11678-RP02-50
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