Anti-DMBT1 Antibody

Cat: 11678-RP02
Contact us:
+86-400-890-9989
order@sinobiological.com
Distributors
All DMBT1 Reagents
CRO Services
Product recommended

All DMBT1 Reagents
Anti-DMBT1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-DMBT1 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human DMBT1
Immunogen
Recombinant Human DMBT1 protein (Catalog#11678-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human DMBT1 (rh DMBT1; Catalog#11678-H08H; NP_004397.2; Met 1-Ser 220). DMBT1 specific IgG was purified by human DMBT1 affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-DMBT1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-DMBT1 Antibody (Rabbit Polyclonal antibody) Images
Human DMBT1/Muclin Immunohistochemistry(IHC) 4290
Immunochemical staining of human DMBT1 in human colon carcinoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Anti-DMBT1 Antibody Alternative Names
Anti-GP340 Antibody;Anti-muclin Antibody
DMBT1 Background Information

Deleted in malignant brain tumors 1 protein, also known as glycoprotein 340, surfactant pulmonary-associated D-binding protein, DMBT1 and GP340, is a secreted protein which belongs to the DMBT1 family. DMBT1 contains 2 CUB domains, 14 SRCR domains and 1 ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are involved in the development of glioma (GLM). Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas , and ependymomas. 

DMBT1 may be considered as a candidate tumor suppressor for brain, lung, esophageal, gastric, and colorectal cancers. It may play roles in mucosal defense system, cellular immune defense and epithelial differentiation. DMBT1 may play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. It may be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. DMBT1 may function as a binding protein in saliva for the regulation of taste sensation. It binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission.

Full Name
deleted in malignant brain tumors 1
References
  • Mollenhauer J., et al.,(1997), DMBT1, a new member of the SRCR superfamily on chromosome 10q25.3-q26.1 is deleted in malignant brain tumours. Nat. Genet. 17:32-39.
  • Holmskov U., et al., (1999), Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D.Proc. Natl. Acad. Sci. U.S.A. 96:10794-10799.
  • Mollenhauer J., et al.,(1999), The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability.Oncogene 18:6233-6240.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-DMBT1 Antibody Mouse Monoclonal ELISA 11678-MM08
    Anti-DMBT1 Antibody Rabbit Polyclonal ELISA 11678-RP01
    info info
    添加购物车成功! 添加购物车失败!