DKKL1/Soggy-1/SGY-1

Dickkopf-like 1 (DKKL1) or soggy 1, is a glycoprotein unique to mammals that is expressed primarily in developing spermatocytes and localized in the acrosome of mature sperm. It is also expressed in the trophectoderm / placental lineage. This glycoprotein is secreted by postmeiotic male germ cells. DKKL1 is a member of the Dickkopf (DKK) family, a group of proteins that are characterized as secreted antagonists of Wnt signal transduction proteins. In mammals, embryos lacking DKKL1 protein developed into viable, fertile adults. DKKL1, either directly or indirectly, facilitates the ability of sperm to penetrate the zona pellucid. DKKL1 is related to the sperm apoptotic procession. Molecular analyses identified the Fas death ligand (FasL) as a target for DkkL1 pro-apoptotic activity in adult mice. DKKL1 is considered as a negative regulator of adult testic homeostasis and identifies a novel, DKKL1 / FasL- dependent, regulation that specifically controls the number of postpubertal spermatocytes.

DKKL1(Soggy-1,SGY-1) Related Areas

Signal Transduction>>Wnt Signaling Pathway>>Wnt Inhibitor>>DKKL1

Stem Cell>>Wnt Signaling Pathway>>Wnt Inhibitor>>DKKL1

DKKL1(Soggy-1,SGY-1) Alternative Names

UNQ735, PRO1429, CT34, SGY, SGY-1, SGY1 [Homo sapiens]

AI414495, SGY, SGY-1, SGY1, Soggy, mSgy [Mus musculus]

Summaries for DKKL1(Soggy-1,SGY-1)

Entrez Gene summary for DKKL1(Soggy-1,SGY-1):

The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

OMIM - description for DKKL1(Soggy-1,SGY-1):

Wikipedia summary for DKKL1(Soggy-1,SGY-1):

Human DKKL1(Soggy-1,SGY-1) Protein General Information

 

• Protein names: Recommended name: Dickkopf-like protein 1 Alternative name(s): Cancer/testis antigen 34 Short name=CT34 Protein soggy-1 Short name=SGY-1
• Sequence length: 242 AA.
• Domain: Signal
• Sequence similarities: To the N-terminal section of DKK-3.
• Post-translational modification: N-glycosylated.
• Subcellular location: Secreted.

General information above from UniProt

Function for DKKL1(Soggy-1,SGY-1) Protein

UniProtKB:

Genatlas:

Homology for human DKKL1(Soggy-1,SGY-1)

• ortholog to murine Dkkl1