DKK-1 Protein & Antibody (DKK1, Dickkopf 1)

Dickkopf related protein 1

DKK-1 Alternative Names

DKK-1, DKK1, Dickkopf 1, hDKK 1, SK

DKK-1 Protein & Antibody

Sino Biological offers a comprehensive set of research tools (proteins, antibodies) for DKK family related research. Our antibody products include mouse monoclonal and rabbit polyclonal antibodies for application such as ELISA, Western Blotting, IHC, etc. All of our antibodies were generated with recombinant full length protein as immunogen, which ensures better binding affinity and specificity to the native protein.

DKK-1 Protein, Recombinant

Molecule	Species	Description	Cat. No
DKK-1	Human	DKK-1/DKK1 Protein, Recombinant	10170-H08H
DKK-1	Rhesus macaque	DKK-1/DKK1 Protein, Recombinant	11089-K08H
DKK-1	Rhesus macaque	DKK-1/DKK1 Protein, Recombinant (with mouse Fc tag)	11089-K05H

  10170-H08H: The ED₅₀ for this effect is approximately 0.21 µg/mL in the presence of 100 ng/mL of mouse Wnt3a. Measured by its ability to inhibit Wnt3a-induced alkaline phosphatase production by C3H10T1/2 cells.

  11089-K08H: The ED₅₀ for this effect is typically 0.3-1.5 µg/mL in the presence of 10 ng/mL of Wnt3a. Measured by its ability to inhibit Wnt3a induced alkaline phosphatase production by C3H10T1/2 2A6 mouse embryonal fibroblast cells .

DKK-1 Antibody

Molecule	Application	Description	Cat. No
Human DKK-1	ELISA	Mouse Monoclonal Antibody	10170-MM03
Human DKK-1	WB, ELISA	DKK-1 Antibody, Rabbit MAb	10171-R003
Human DKK-1	ELISA	Rabbit Polyclonal Antibody	10170-RP01

DKK-1 ELISA Kit

Molecule	Application	Description	Cat. No
Human DKK-1	ELISA	DKK-1 ELISA Kit	SEK10170

DKK-1 Related Areas

Signal Transduction>>Wnt Signaling Pathway>>Wnt Inhibitor>>DKK1

Stem Cell>>Wnt Signaling Pathway>>Wnt Inhibitor>>DKK1

DKK-1 Related Products

Protein Products

Molecule	Species	Description
DKK-3/DKK3	Human	DKK-3/DKK3 Protein, Recombinant
DKK-3/DKK3	Mouse	DKK-3/DKK3 Protein, Recombinant
SFRP1	Human	SFRP1 Protein, Recombinant
SFRP1	Mouse	SFRP1 Protein, Recombinant
SFRP1	Rat	SFRP1 Protein, Recombinant
SFRP2	Mouse	SFRP2 Protein, Recombinant
SFRP4	Human	SFRP4 Protein, Recombinant
SFRP4	Mouse	SFRP4 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human DKK-3/DKK3	WB, ELISA	Mouse Monoclonal Antibody
Human DKK-3/DKK3	ELISA	Rabbit Polyclonal Antibody
Human DKK3/DKK-3	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Mouse DKK3/DKK-3	WB, ELISA	Rabbit Polyclonal Antibody
Mouse DKK3/DKK-3	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
DKK-1/DKK1	Human	Homo sapiens DKK-1/DKK1 cDNA Clone(NM_012242.2)
DKK-2/DKK2	Human	Homo sapiens DKK-2/DKK2 cDNA Clone
DKK-2/DKK2	Mouse	Mus musculus DKK-2/DKK2 cDNA Clone
DKK-3/DKK3	Human	Homo sapiens DKK-3/DKK3 transcript variant 3 cDNA Clone(NM_001018057.1)
DKK-3/DKK3	Mouse	Mus musculus DKK-3/DKK3 cDNA Clone
DKK-4/DKK4	Human	Mus musculus DKK-4/DKK4 cDNA Clone
SFRP1	Mouse	Mus musculus SFRP1 cDNA Clone
SFRP2	Mouse	Mus musculus SFRP2 cDNA Clone
SFRP3	Human	Homo sapiens SFRP3/FRZB/FIZ DNA ORF Clone(NM_001463.2)
SFRP4	Human	Homo sapiens SFRP4 cDNA Clone(NM_003014.3)
SFRP4	Mouse	Mus musculus SFRP4 cDNA Clone
SFRP5	Human	Homo sapiens SFRP5 cDNA Clone(NM_003015.3)
SFRP5	Mouse	Mus musculus SFRP5 cDNA Clone
WIF1	Human	Homo sapiens WIF 1 cDNA Clone(NM_007191.3)

DKK-1 Background

Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.

DKK-1 Related Studies

1. Horwitz EM. (2004) Dkk-1-mediated expansion of adult stem cells. Trends Biotechnol. 22(8): 386-8.
2. Jiang T, et al. (2009) Clinical significance of serum DKK-1 in patients with gynecological cancer. Int J Gynecol Cancer. 19(7): 1177-81.