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DKK1/Dkk-1  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
  • Slide 1
10170-H08H-5
10170-H08H-20
10170-H08H-100
5 µg 
20 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
57248-M08H-50
57248-M08H-10
50 µg 
10 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
11089-K08H-5
11089-K08H-20
11089-K08H-100
5 µg 
20 µg 
100 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
11089-K05H-5
11089-K05H-20
11089-K05H-100
5 µg 
20 µg 
100 µg 
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DKK1/Dkk-1 Related Area

DKK1/Dkk-1 Related Pathways

DKK1/Dkk-1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

DKK1/Dkk-1 Summary & Protein Information

DKK1/Dkk-1 Background

Gene Summary: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
General information above from NCBI
Subunit structure: Interacts with LRP6. Interacts (via the C-termianl Cys- rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt- mediated signaling.
Domain: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity).
Subcellular location: Secreted.
Tissue specificity: Placenta.
Sequence similarity: Belongs to the dickkopf family.
General information above from UniProt

Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.

DKK1/Dkk-1 Alternative Name

mdkk-1, []
SK,DKK-1, [homo-sapiens]
S,Dickkopf 1,DKK1,DKK-1,hDKK 1,SK, [human]
mdkk-1, [mus-musculus]

DKK1/Dkk-1 Related Studies

  • Horwitz EM. (2004) Dkk-1-mediated expansion of adult stem cells. Trends Biotechnol. 22(8): 386-8.
  • Jiang T, et al. (2009) Clinical significance of serum DKK-1 in patients with gynecological cancer. Int J Gynecol Cancer. 19(7): 1177-81.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"