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DKK-1 Neutralizing Antibody

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    Human DKK1 Antibody Product Information
    Immunogen:Recombinant Human DKK-1 Protein (Catalog#10170-H08H)
    Clone ID:R015
    Ig Type:Rabbit IgG
    Concentration:
    Endotoxin:< 3 EU/mg
    Formulation:0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0
    Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human DKK-1 (rh DKK-1; Catalog#10170-H08H; NP_036374.1; Met2-His266) and was produced using recombinant antibody technology.
    Other DKK1 Antibody Products
    Immunochemical staining of human CD40 in human tonsil with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
    DKK1/Dkk-1 Background

    Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.

    Human DKK1/Dkk-1 References
  • Horwitz EM. (2004) Dkk-1-mediated expansion of adult stem cells. Trends Biotechnol. 22(8): 386-8.
  • Jiang T, et al. (2009) Clinical significance of serum DKK-1 in patients with gynecological cancer. Int J Gynecol Cancer. 19(7): 1177-81.
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    Size / Price
    Catalog: 10170-R015-500
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"