|ELISA(Det)||1:1000-1:10000||This antibody will detect Human DKK1 / Dkk-1 in ELISA pair set (Catalog: # SEKA10170). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 10170-MM08).|
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.
|Product Description||Host||Clonality||Application||Catalog# (PDF)|
|DKK-1 Neutralizing Antibody||Rabbit||Monoclonal||Neutralization||10170-R015|