DEP1 / PTPRJ Protein

Protein tyrosine phosphatase, receptor type, J Protein

DEP1 / PTPRJ Products

DEP1 / PTPRJ Protein, Recombinant

Molecule	Species	Description	Cat. No
DEP1 / PTPRJ	Human	PTPRJ Protein, Recombinant, with His Tag	13165-H07E

DEP1 / PTPRJ cDNA Clone

Molecule	Species	Description	Cat. No
DEP1 / PTPRJ	Human	PTPRJ cDNA Clone	HG13165-G

DEP1 / PTPRJ Related Areas

Signal Transduction>>Phosphatase & Regulator>>DEP1 / PTPRJ

Enzyme>>Phosphatase & Regulator>> DEP1 / PTPRJ

DEP1 / PTPRJ Alternative Names

CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1, CD148 antigen, DEP-1, HPTP eta, R-PTP-J, density-enhanced phosphatase 1, human density enhanced phosphatase-1, protein tyrosine phosphatase, receptor type, J polypeptide, protein-tyrosine phosphatase eta, protein-tyrosine phosphatase receptor type J [Homo sapiens]

rCG_26744, DEP-1, density enhanced phosphatase-1, receptor-type tyrosine-protein phosphatase eta [Mus musculus]

DEP1 / PTPRJ Background

DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1 / PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. DEP1 / PTPRJ is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. In stable MCF-7 cell lines lines, induction of DEP-1 expression inhibited breast cancer cell growth by 5-10-fold. These data describe PTPs expressed and regulated in breast cancer cell lines during differentiation and identify one PTP, DEP-1, that inhibits the growth of breast cancer cells in vitro.

DEP1 / PTPRJ Related Studies

1. Holsinger LJ, et al. (2002) The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120. Oncogene. 21(46): 7067-76.
2. Huang X, et al. (2009) Natural variation at the DEP1 locus enhances grain yield in rice. Nat Genet. 41(4): 494-7.
3. Kuramochi S, et al. (1996) Molecular cloning and characterization of Byp, a murine receptor-type tyrosine phosphatase similar to human DEP-1. FEBS Lett. 378(1): 7-14.