DEP-1 (Protein|Antibody|cDNA Clone|ELISA Kit)

All DEP-1 reagents are produced in house and quality controlled, including 3 DEP-1 Antibody, 1 DEP-1 Protein, 1 DEP-1 qPCR. All DEP-1 reagents are ready to use.

Recombinant DEP-1 proteins are expressed by E. coli with fusion tags as N-His.

DEP-1 antibodies are validated with different applications, which are IHC-P, ELISA.

DEP-1 Protein (1)

Species

DEP-1 Protein, Human, Recombinant (aa 997-1337, His Tag)

13165-H07E

Expression host: E. coli

Human DEP1 / PTPRJ Protein 10217
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DEP-1 Antibody (3)

Application Clonality
Host

Anti-DEP-1 Antibody

102361-T08

Specificity: Mouse

Application: IHC-P

Clonality: PAb

Mouse DEP1 / PTPRJ Immunohistochemistry(IHC) 14668

Anti-DEP-1 Antibody

13165-MM10

Specificity: Human

Application: ELISA

Clonality: MAb

Anti-DEP-1 Antibody

13165-T16

Specificity: Human

Application: ELISA

Clonality: PAb

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DEP-1 qPCR Primer (1)

DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1 / PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. DEP1 / PTPRJ is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. In stable MCF-7 cell lines lines, induction of DEP-1 expression inhibited breast cancer cell growth by 5-1-fold. These data describe PTPs expressed and regulated in breast cancer cell lines during differentiation and identify one PTP, DEP-1, that inhibits the growth of breast cancer cells in vitro.
Protein
Antibody
qPCR
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