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>Human Cell Expressed
>Human CLEC4N / CLEC6A / Dectin-2 Protein (Fc Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
C-type lectin domain family 6, member A,human IgG1-Fc chimera Protein Datasheet
DECTIN2 Protein Price Inquiry ( Available Sizes )
DECTIN2 Protein Product Information
|Synonym :||CLECSF10 DECTIN2 CLEC6A|
A DNA sequence encoding the human DECTIN2 (NP_001007034) (Thr 42- Leu209) was expressed, fused with the Fc region of human IgG1 at the N-terminus.
|Expression Host:||Human Cells|
DECTIN2 Protein QC Testing
|Purity:||> 80 % as determined by SDS-PAGE||SDS-PAGE:
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Glu|
The recombinant human DECTIN2 /Fc comprises 428 amino acids and has a predicted molecular mass of 47.9 kDa. The apparent molecular mass of the protein is approximately 52 kDa in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
DECTIN2 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
DECTIN2 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat No|
|CLEC6A||Human||DECTIN2 Protein, Recombinant||10250-H01H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat No|
|Mouse CLEC6A||WB, ELISA||CLEC4N / CLEC6A / Dectin-2 Antibody||50267-R001|
|Mouse CLEC6A||WB, ELISA||CLEC4N / CLEC6A / Dectin-2 Antibody||50267-RP01|
|Mouse CLEC6A||WB, ELISA||CLEC4N / CLEC6A / Dectin-2 Antibody (Antigen Affinity Purified)||50267-RP02|
DECTIN2 Protein Description
Dectin 2 contains 1 C-type lectin domain and belongs to the C-type lectin domain family. It is expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Dectin 2 functions as a receptor for alpha-mannans on C. albicans hypheas and plays an important role in the host defense against C. albicans infection by inducing TH17 cell differentiation. It binds high-mannose carbohydrates in a Ca2+-dependent manner and recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Dectin 2 transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway.
- Doyle SL. et al., 2006, Biochem Pharmacol. 72 (9): 1102-13.
- Beutler B. et al., 2006, Annu Rev Immunol. 24: 353-89.
- Song WY. et al., 1995, Science. 270 (5243): 1804-6.