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Discoidin domain receptor tyrosine kinase 2 Protein Datasheet
DDR2 Protein Price Inquiry ( Available Sizes )
DDR2 Protein Product Information
A DNA sequence encoding the rat DDR2 (B1WC09)(Met1-Arg399) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
|Expression Host:||Human Cells|
DDR2 Protein QC Testing
|Purity:||> 80% as determined by SDS-PAGE||SDS-PAGE:
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Gln 24|
|Molecular Mass:||The recombinant rat DDR2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 617 amino acids and has a predicted molecular mass of 69.5 kDa. The apparent molecular mass of the protein is approximately 110 kDa in SDS-PAGE under reducing conditions.|
|Formulation:||Lyophilized from sterile PBS, pH7.4.
DDR2 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
DDR2 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|DDR2||Human||DDR2/Fc Protein, Recombinant||10209-H02H|
|DDR2||Human||DDR2 / CD167b / NTRKR3 (aa 422-855) Protein, Recombinant, with GST Tag||10209-H20B1|
|DDR2||Human||DDR2 Protein, Recombinant||10209-HCCH|
|DDR2||Mouse||DDR2 Protein, Recombinant||50541-M08H|
|DDR2||Rat||DDR2 Protein, Recombinant||80341-R02H|
|DDR2||Rat||DDR2 Protein, Recombinant||80341-R08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Mouse DDR2||WB, ELISA||DDR2 Antibody||50541-RP01|
|Mouse DDR2||WB, ELISA||DDR2 Antibody (Antigen Affinity Purified)||50541-RP02|
DDR2 Protein Description
Discoidin domain receptor 2 (DDR2), also known as TYR010 and TKT, is a type I transmembrane glycoprotein and belongs to discoidin-like domain containing subfamily of receptor tyrosine kinases (RTKs). All family members share the discoidin (DS) homology domain, a long juxtamembrane domain, a transmembrane region, and a tyrosine kinase domain. DDR2 is mainly expressed in mesenchymal cells and is unique among RTKs in that its ligand is fibrillar collagen rather than a growth factor-like peptide. Ligand binding induces DDR2 autophosphorylation in the cytoplasmic domain and the adaptor proteins SHC have been identified as key signaling mediators in DDR2 signal transduction. Activation of DDR2 by collagen induces upregulation of MMP-1, -2, and -13 as well as DDR2 itself. It has been suggested that DDR2 plays an important role in mediating chondrocyte, hepatic stellate cells and fibroblast migration and proliferation by MMP2–dependent mechanism. Accordingly, aberrant expression of DDR2 is implicated in tumor growth and invasion.
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