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Rat DDR2 Kinase / CD167b Protein (His Tag)
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Rat DDR2 Kinase / CD167b Protein (His Tag) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
80341-R08H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Discoidin domain receptor tyrosine kinase 2 Protein Datasheet

 

DDR2 Protein Price Inquiry ( Available Sizes )

DDR2 Protein Product Information

Synonym : DDR2
Protein Construction:

A DNA sequence encoding the rat DDR2(B1WC09)(Met1-Arg399) was expressed with a polyhistidine tag at the C-terminus.

Source: Rat
Expression Host: Human Cells

DDR2 Protein QC Testing

Purity: > 90 % as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

DDR2 protein

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Gln 24
Molecular Mass:

The recombinant rat DDR2 comprises 387 amino acids and predicts a molecular mass of 43.9 kDa. The apparent molecular mass of  the recombinant protein is approximately 58 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

DDR2 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

DDR2 Protein Related Products & Topics

Related Areas:

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>DDR2/CD167b

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>DDR2/CD167b

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>DDR2/CD167b

Immunology>>Cluster of Differentiation>>DDR2/CD167b

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
DDR2 Human DDR2/Fc Protein, Recombinant 10209-H02H
DDR2 Human DDR2 / CD167b / NTRKR3 (aa 422-855) Protein, Recombinant, with GST Tag 10209-H20B1
DDR2 Human DDR2 Protein, Recombinant 10209-HCCH
DDR2 Mouse DDR2 Protein, Recombinant 50541-M08H
DDR2 Rat DDR2 Protein, Recombinant 80341-R02H
DDR2 Rat DDR2 Protein, Recombinant 80341-R08H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Mouse DDR2 WB, ELISA DDR2 Antibody 50541-RP01
Mouse DDR2 WB, ELISA DDR2 Antibody (Antigen Affinity Purified) 50541-RP02

DDR2 Protein Description

Discoidin domain receptor 2 (DDR2), also known as TYR010 and TKT, is a type I  transmembrane glycoprotein and belongs to discoidin-like domain containing subfamily of receptor tyrosine kinases (RTKs). All family members share the discoidin (DS) homology domain, a long juxtamembrane domain, a transmembrane region, and a tyrosine kinase domain. DDR2 is mainly expressed in mesenchymal cells and is unique among RTKs in that its ligand is fibrillar collagen rather than a growth factor-like peptide. Ligand binding induces DDR2 autophosphorylation in the cytoplasmic domain and the adaptor proteins SHC have been identified as key signaling mediators in DDR2 signal transduction. Activation of DDR2 by collagen induces upregulation of MMP-1, -2, and -13 as well as DDR2 itself. It has been suggested that DDR2 plays an important role in mediating chondrocyte, hepatic stellate cells and fibroblast migration and proliferation by MMP2–dependent mechanism. Accordingly, aberrant expression of DDR2 is implicated in tumor growth and invasion.

References

  1. Voqel W. et al., 1997, Mol Cell. 1: 13-23.
  2. Alves F. et al., 1995, Oncogene. 10: 609-18.
  3. Leitinqer B. et al., 2006. Matrix Biol. 25: 355-64.
  4. Wall SJ. et al., 2005, J. Biol. Chem. 48: 40187-94.
  5. Ferri N. et al., 2004, Am J Pathol. 164: 1575-85.
  6. Ikeda K. et al., 2002, J Biol Chem. 277: 19206-12.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"