DDR2 Protein & Antibody (CD167b Protein)

Discoidin Domain Receptor Tyrosine Kinase 2 (Cluster of Differentiation 167b)

DDR2 Products

DDR2 Protein, Recombinant

Molecule	Species	Description	Cat. No
DDR2	Human	DDR2/Fc Protein, Recombinant	10209-H02H
DDR2	Human	DDR2 Protein, Recombinant	10209-HCCH
DDR2	Mouse	DDR2 Protein, Recombinant	50541-M08H

  10209-H02H:  Immobilized Rat tail Collagen I at 10 µg/mL can bind recombinant human DDR2-Fc Chimera with a linear range of 2.5-80 ng/ml. Scatchard analysis showed the affinity constant (Kd) of recombinant human DDR2-Fc Chimera bound to rat tail collagen I was 6.8 nM. Measured by its binding ability in a functional ELISA.

  50541-M08H:  Measured by its ability to bind rat tail Collagen I in a functional Elisa.

DDR2 Antibody

Molecule	Application	Description	Cat. No
Mouse DDR2	WB, ELISA	DDR2 Antibody	50541-RP01
Mouse DDR2	WB, ELISA	DDR2 Antibody (Antigen Affinity Purified)	50541-RP02

DDR2 cDNA Clone

Molecule	Species	Description	Cat. No
DDR2	Human	Homo sapiens DDR2 transcript variant 1 cDNA Clone(NM_001014796.1)	HG10209-M
DDR2	Mouse	Mus musculus DDR2 cDNA Clone	MG50541-M
DDR2	Rat	DDR2 cDNA Clone / ORF Clone	RG80341-G

DDR2 Alternative Names

DDR2, NTRKR3, TYRO10, CD167b, RP11-572K18.1, MIG20a, TKT [Homo sapiens]

Ddr2, Ntrkr3, tyro10, CD167b, AW495251 [Mus musculus]

DDR2 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>DDR2/CD167b

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>DDR2/CD167b

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>DDR2/CD167b

Immunology>>Cluster of Differentiation>>DDR2/CD167b

DDR2 Background

Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.

DDR2 Related Studies

et al.
1. Olaso E, et al. (2001) DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells. J Clin Invest. 108(9): 1369-78.
2. Zhang W, et al. (2006) Expression of discoidin domain receptor 2 (DDR2) extracellular domain in pichia pastoris and functional analysis in synovial fibroblasts and NIT3T3 cells. Mol Cell Biochem. 290(1-2): 43-53.
3. Leitinger B, et al. (2006) The discoidin domain receptor DDR2 is a receptor for type X collagen. Matrix Biol. 25(6): 355-64.
4. Leitinger B, et al. (2004) The D2 period of collagen II contains a specific binding site for the human discoidin domain receptor, DDR2. J Mol Biol. 344(4): 993-1003.