DDR1 Kinase Protein & Antibody (MCK10, CD167)

Discoidin Domain Receptor Tyrosine Kinase 1 (Mammary Carcinoma Kinase 10, Cluster of Differentiation 167)

DDR1 Kinase Protein Products

DDR1 Kinase Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
DDR1/MCK10/CD167	Human	DDR1 / MCK10 / CD167 Protein, Recombinant	10730-H08H
DDR1/MCK10/CD167	Human	DDR1 / CD167 (aa 444-913) Protein, Recombinant, with GST Tag	10730-H20B1
DDR1/MCK10/CD167	Mouse	DDR1 / CD167 Protein, Recombinant	50829-M02H
DDR1/MCK10/CD167	Mouse	DDR1/MCK10 / CD167 Protein, Recombinant	50829-M08H
DDR1/MCK10/CD167	Mouse	DDR1 / CD167 Protein, Recombinant, with GST Tag	50829-M020B1
DDR1/MCK10/CD167	Rat	DDR1 Protein, Recombinant	80440-R08H

DDR1 Kinase Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human DDR1/MCK10/CD167	WB, ELISA	DDR1 / MCK10 / CD167 Rabbit PAb	10730-RP01
Human DDR1/MCK10/CD167	WB, ELISA	DDR1/ MCK10 / CD167 Antibody, Rabbit Pab (Antigen Affinity Purified)	10730-RP02
Human DDR1/MCK10/CD167	WB, ELISA	DDR1 / MCK10 / CD167 Antibody	10730-MM05
Human DDR1/MCK10/CD167	WB, ELISA	DDR1 / MCK10 / CD167 Antibody	10730-R203

DDR1 Kinase cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
DDR1/MCK10/CD167	Human	Homo sapiens DDR1 / MCK10 / CD167 cDNA Clone(NM_001954.4)	HG10730-M
DDR1/MCK10/CD167	Mouse	Mouse DDR1 / MCK10 / CD167 cDNA Clone / ORF Clone	MG50829-G

DDR1 Kinase Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>DDR1 Kinase/MCK10/CD167

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>DDR1 Kinase/MCK10/CD167

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>DDR1 Kinase/MCK10/CD167

Immunology>>Cluster of Differentiation>>Other>>DDR1 Kinase/MCK10/CD167

DDR1 Kinase Alternative Names

DDR1, DDR, MCK10, CD167, PTK3A, CAK, DAAP-278B20.1, EDDR1, NEP, NTRK4, PTK3, RTK6, TRKE [Homo sapiens]

Ddr1, CD167a, PTK3A, Cak, 6030432F18, AI323681, Nep [Mus musculus]

DDR1 Kinase Background

Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.

DDR1 Kinase Related Studies

Hou G, et al. (2001) The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. J Clin Invest. 107(6): 727-35.
Ongusaha PP, et al. (2003) p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J. 22(6): 1289-301.
Jönsson M, et al. (2001) Repression of Wnt-5a impairs DDR1 phosphorylation and modifies adhesion and migration of mammary cells. J Cell Sci. 114(11): 2043-53.