Anti-DDR1 Antibody

Cat: 10730-MM05

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Anti-DDR1 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-DDR1 Antibody
Validated applications
ELISA,FCM
Species reactivity
Reacts with: Human
Specificity
Human DDR1
Immunogen
Recombinant Human DDR1 protein (Catalog#10730-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human DDR1 / CD167a (rh DDR1; Catalog#10730-H08H; NP_001945.3; Met 1-Thr 416). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #10B6E5A11
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-DDR1 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
FCM 1:25-1:100  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-DDR1 Antibody (Mouse Monoclonal antibody) Images
Human DDR1/MCK10/CD167 Flow Cytometry (FC) 5191
Flow cytometric analysis of Human DDR1(CD167a) expression on  MCF-7 cells.  Cells were stained with purified anti-Human DDR1(CD167a), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Anti-DDR1 Antibody Alternative Names
Anti-CAK Antibody;Anti-CD167 Antibody;Anti-DDR Antibody;Anti-EDDR1 Antibody;Anti-HGK2 Antibody;Anti-MCK10 Antibody;Anti-NEP Antibody;Anti-NTRK4 Antibody;Anti-PTK3 Antibody;Anti-PTK3A Antibody;Anti-RTK6 Antibody;Anti-TRKE Antibody
DDR1 Background Information

Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.

Full Name
discoidin domain receptor tyrosine kinase 1
References
  • Hou G, et al. (2001) The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. J Clin Invest. 107(6): 727-35.
  • Ongusaha PP, et al. (2003) p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J. 22(6): 1289-301.
  • Jönsson M, et al. (2001) Repression of Wnt-5a impairs DDR1 phosphorylation and modifies adhesion and migration of mammary cells. J Cell Sci. 114(11): 2043-53.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-DDR1 Antibody Rabbit Polyclonal WB,IHC-P 80440-T40
    Anti-DDR1 Antibody Rabbit Monoclonal WB,ELISA,IP 10730-R203
    Anti-DDR1 Antibody Rabbit Monoclonal ELISA(Cap) 10730-R205
    Anti-DDR1 Antibody Mouse Monoclonal ELISA,FCM 10730-MM05T
    Anti-DDR1 Antibody (APC) Mouse Monoclonal FCM 10730-MM05-A
    Anti-DDR1 Antibody (PE) Mouse Monoclonal FCM 10730-MM05-P
    Anti-DDR1 Antibody Rabbit Polyclonal ELISA 10730-RP01
    Anti-DDR1 Antibody Rabbit Polyclonal WB,ELISA,IP 10730-RP02
    Anti-DDR1 Antibody Rabbit Polyclonal ELISA 10730-T16
    Anti-DDR1 Antibody Rabbit Monoclonal ELISA(Det) 10730-R017
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