Anti-DDR1 Antibody

Cat: 10730-MM05

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Anti-DDR1 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-DDR1 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human DDR1
Recombinant Human DDR1 protein (Catalog#10730-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human DDR1 / CD167a (rh DDR1; Catalog#10730-H08H; NP_001945.3; Met 1-Thr 416). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG1 Clone #10B6E5A11
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-DDR1 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
FCM 1:25-1:100  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-DDR1 Antibody (Mouse Monoclonal antibody) Images
Human DDR1/MCK10/CD167 Flow Cytometry (FC) 5191
Flow cytometric analysis of Human DDR1(CD167a) expression on MCF-7 cells. Cells were stained with purified anti-Human DDR1(CD167a), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Anti-DDR1 Antibody Alternative Names
Anti-CAK Antibody;Anti-CD167 Antibody;Anti-DDR Antibody;Anti-EDDR1 Antibody;Anti-HGK2 Antibody;Anti-MCK10 Antibody;Anti-NEP Antibody;Anti-NTRK4 Antibody;Anti-PTK3 Antibody;Anti-PTK3A Antibody;Anti-RTK6 Antibody;Anti-TRKE Antibody
DDR1 Background Information

Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.

Full Name
discoidin domain receptor tyrosine kinase 1
  • Hou G, et al. (2001) The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. J Clin Invest. 107(6): 727-35.
  • Ongusaha PP, et al. (2003) p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J. 22(6): 1289-301.
  • Jönsson M, et al. (2001) Repression of Wnt-5a impairs DDR1 phosphorylation and modifies adhesion and migration of mammary cells. J Cell Sci. 114(11): 2043-53.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-DDR1 Antibody Rabbit Polyclonal WB,IHC-P 80440-T40
    Anti-DDR1 Antibody Rabbit Monoclonal WB,ELISA,IP 10730-R203
    Anti-DDR1 Antibody Rabbit Monoclonal ELISA(Cap) 10730-R205
    Anti-DDR1 Antibody (APC) Mouse Monoclonal FCM 10730-MM05-A
    Anti-DDR1 Antibody (PE) Mouse Monoclonal FCM 10730-MM05-P
    Anti-DDR1 Antibody Rabbit Polyclonal ELISA 10730-RP01
    Anti-DDR1 Antibody Rabbit Polyclonal WB,ELISA,IP 10730-RP02
    Anti-DDR1 Antibody Rabbit Polyclonal ELISA 10730-T16
    Anti-DDR1 Antibody Rabbit Monoclonal ELISA(Det) 10730-R017
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