DCIR / CLEC4A Protein & Antibody (CLECSF6)

Dendritic Cell Immunoreceptor / C-type Lectin domain family 4, member A (C-type Lectin Superfamily member 6)

DCIR / CLEC4A Products

DCIR / CLEC4A Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
DCIR/CLEC4A/CLECSF6	Human	DCIR / CLEC4A / CLECSF6 Protein, Recombinant	11476-H07H
DCIR/CLEC4A/CLECSF6	Rat	DCIR / CLEC4A2 Protein, Recombinant	80267-R07H

DCIR / CLEC4A Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human DCIR/CLEC4A/CLECSF6	WB, ELISA	DCIR / CLEC4A / CLECSF6 Antibody, Mouse MAb	11476-MM02
Human DCIR/CLEC4A/CLECSF6	WB, ELISA	DCIR / CLEC4A / CLECSF6 Antibody, Mouse MAb	11476-MM08
Human DCIR/CLEC4A/CLECSF6	WB, ELISA	DCIR / CLEC4A / CLECSF6 Antibody, Rabbit PAb	11476-RP01
Human DCIR/CLEC4A/CLECSF6	WB, ELISA	DCIR / CLEC4A / CLECSF6 Antibody, Rabbit PAb (Antigen Affinity Purified)	11476-RP02

DCIR / CLEC4A Elisa Pair Set

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human DCIR/CLEC4A/CLECSF6	ELISA	DCIR / CLEC4A / CLECSF6 Elisa Pair Set	SEK11476

DCIR / CLEC4A cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
DCIR/CLEC4A/CLECSF6	Human	Homo sapiens DCIR / CLEC4A / CLECSF6 cDNA Clone	HG11476-M

DCIR / CLEC4A Related Areas

Immunology>>Adhesion Molecule>>Lectin>>DCIR/CLEC4A/CLECSF6

DCIR / CLEC4A Alternative Names

DCIR, CLEC4A, CLECSF6, HDCGC13P, DDB27, LLIR [Homo sapiens]

DCIR, Clec4a, Clecsf6, Dcir1 [Mus musculus]

DCIR / CLEC4A Background

Dendritic cell immunoreceptor (DCIR), also known as C-type lectin domain family 4 member A (CLEC4A), C-type lectin superfamily member 6 (CLECSF6), is a single-pass type II C-type lectin receptor expressed mainly in dendritic cells (DCs), which is a negative regulator of DC expansion and has a crucial role in maintaining the homeostasis of the immune system. The Dectin-2 family of C-type lectins that includes Dectin-2, BDCA-2, DCIR, DCAR, Clecsf8 and Mincle. These type II receptors contain a single extracellular carbohydrate recognition domain and have diverse functions in both immunity and homeostasis. DCIR is the only member of the family which contains a cytoplasmic signalling motif and has been shown to act as an inhibitory receptor, while BDCA-2, Dectin-2, DCAR and Mincle all associate with FcRgamma chain to induce cellular activation, including phagocytosis and cytokine production. Dectin-2 and Mincle have been shown to act as pattern recognition receptors for fungi, while DCIR acts as an attachment factor for HIV. In addition to pathogen recognition, DCIR has been shown to be pivotal in preventing autoimmune disease by controlling dendritic cell proliferation. DCIR expressed on antigen presenting cells and granulocytes and acts as an inhibitory receptor via an intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM). It may also be involved via its ITIM motif in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. Additionally, DCIR can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4(+) T cells from human immature monocyte-derived DCs. DCIR acts as a ligand for HIV-1 and is involved in events leading to productive virus infection.

DCIR / CLEC4A Related Studies

1. Kanazawa N, et al. (2004) Signaling and immune regulatory role of the dendritic cell immunoreceptor (DCIR) family lectins: DCIR, DCAR, dectin-2 and BDCA-2. Immunobiology. 209(1-2): 179-90.
2. Fujikado N, et al. (2008) Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells. Nat Med. 14(2): 176-80.
3. Lambert AA, et al. (2008) The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways. Blood. 112(4): 1299-307.
4. Graham LM, et al. (2009) The Dectin-2 family of C-type lectins in immunity and homeostasis. Cytokine. 48(1-2): 148-55.