CD299 (Protein|Antibody|cDNA Clone|ELISA Kit)

All CD299 reagents are produced in house and quality controlled, including 13 CD299 Gene, 2 CD299 Lysate, 2 CD299 Protein, 1 CD299 qPCR. All CD299 reagents are ready to use.

Recombinant CD299 proteins are expressed by HEK293 Cells with fusion tags as N-human IgG1-Fc, N-cleavage.

CD299 cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD299 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

CD299 Protein (2)

Species

CD299 Protein, Human, Recombinant (Fc Tag)

10559-H01H

Expression host: HEK293 Cells

Human DC-SIGNR/CD299 Protein 8923

CD299 Protein, Human, Recombinant (ECD)

10559-HNCH

Expression host: HEK293 Cells

Human DC-SIGNR/CD299 Protein 8924
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CD299 cDNA Clone (13)

Human

CD299 qPCR Primer (1)

CD299 Lysate (2)

C-type lectin domain family 4, member M, also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein that is 77% amino acid identical to DC-SIGN, an HIV gp12-binding protein. Though the encoded gene located in the same chromosome, DC-SIGN is expressed solely on dendritic cells, while DC-SIGNR is predominantly found in liver sinusoidal endothelial cells and lymph node, as well as placental endothelium. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. DC-SIGNR appears to selectively recognize and bind many viral surface glycoproteins containing high mannose N-linked oligosaccharides in a calcium-dependent manner, including HIV-1 gp12, HIV-2 gp12, SIV gp12, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S, as well as the cellular adhesion protein ICAM3. DC-SIGNR have been thought to play an important role in establishing HIV infection by enhancing trans-infection of CD4(+)T cells in the regional lymph nodes. It may affect susceptibility to HIV infection by a mechanism that is different in females and males. DC-SIGNR can bind to hepatitis C virus (HCV), and its polymorphism might affect HCV loads supporting the concept that DC-SIGNR contributes to HCV replication efficacy.
Protein
Gene
qPCR
Lysate
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