All DC-SIGN reagents are produced in house and quality controlled, including 12 DC-SIGN Antibody, 2 DC-SIGN ELISA, 26 DC-SIGN Gene, 3 DC-SIGN Lysate, 3 DC-SIGN Protein, 1 DC-SIGN qPCR. All DC-SIGN reagents are ready to use.
Recombinant DC-SIGN proteins are expressed by HEK293 Cells with fusion tags as N-His, N-human IgG1-Fc.
DC-SIGNantibodies are validated with different applications, which are FCM, ELISA(Cap), WB, ELISA, ELISA(Det).
DC-SIGNcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each DC-SIGN of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
DC-SIGNELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.