DC-SIGN Protein (CD209 Protein)

Dendritic Cell-Specific ICAM-3 Grabbing Nonintegrin (Cluster of Differentiation 209)

DC-SIGN Products

DC-SIGN Protein, Recombinant

Molecule	Species	Description	Cat. No
DC-SIGN/CD209	Human	DC-SIGN/CD209/Fc Protein, Recombinant	10200-H01H

DC-SIGN cDNA Clone

Molecule	Species	Description	Cat. No
DC-SIGN/CD209	Human	Homo sapiens DC-SIGN/ CD209 cDNA Clone(NM_021155.2)	HG10200-M

DC-SIGN Alternative Names

DC-SIGN, CD209, DC-SIGN1, CDSIGN, CLEC4L, MGC129965 [Homo sapiens]

DC-SIGN, CD209, Cd209a, DC-SIGN1, CDSIGN, CIRE, Dcsign, MGC130443, SIGN-R1, SIGNR5 [Mus musculus]

DC-SIGN Related Areas

Immunology>>Adhesion Molecule>>Lectin>>DC-SIGN/CD209

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Pathogen Recognition/Uptake>>DC-SIGN/CD209

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>DC-SIGN/CD209

DC-SIGN Background

Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.

DC-SIGN Related Studies

1. Geijtenbeek TB, et al. (2002) DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J Leukoc Biol. 71(6): 921-31.
2. Masso M. (2003) DC-SIGN points the way to a novel mechanism for HIV-1 transmission. MedGenMed. 5(2): 2.
3. Zhou T, et al. (2006) DC-SIGN and immunoregulation. Cell Mol Immunol. 3(4): 279-83.