Anti-DC-SIGN Antibody

Cat: 10200-R061
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Anti-DC-SIGN Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-DC-SIGN Antibody
Validated applications
Species reactivity
Reacts with: Human
Recombinant Human DC-SIGN / CD209 protein (Catalog#10200-H01H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human DC-SIGN / CD209 (rh DC-SIGN / CD209; Catalog#10200-H01H; NP_066978.1; Lys62-Ala404).
Monoclonal Rabbit IgG Clone #061
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-DC-SIGN Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:25000-1:50000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-DC-SIGN Antibody (Rabbit Monoclonal antibody) Images
Human CD209/DC-SIGN Western blot (WB) 13141

Anti-CD209 rabbit monoclonal antibody at 1:500 dilution

Lane A: THP1 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:46 kDa

Observed band size:46 kDa

(We are unsure as to the identity of these extra bands.)

Anti-DC-SIGN Antibody Alternative Names
Anti-CD209 Antibody;Anti-CDSIGN Antibody;Anti-CLEC4L Antibody;Anti-DC-SIGN Antibody;Anti-DC-SIGN1 Antibody;Anti-MGC129965 Antibody
DC-SIGN Background Information

Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
CD209 molecule
  • Geijtenbeek TB, et al. (2002) DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J Leukoc Biol. 71(6): 921-31.
  • Masso M. (2003) DC-SIGN points the way to a novel mechanism for HIV-1 transmission. MedGenMed. 5(2): 2.
  • Zhou T, et al. (2006) DC-SIGN and immunoregulation. Cell Mol Immunol. 3(4): 279-83.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-DC-SIGN Antibody (FITC) Rabbit Monoclonal FCM 10200-R037-F
    Anti-DC-SIGN Antibody (FITC) Mouse Monoclonal FCM 10200-MM01-F
    Anti-DC-SIGN Antibody Mouse Monoclonal ELISA(Cap),FCM 10200-MM01
    Anti-DC-SIGN Antibody Rabbit Polyclonal ELISA 10200-T16
    Anti-DC-SIGN Antibody (PE) Mouse Monoclonal FCM 10200-MM01-P
    Anti-DC-SIGN Antibody Rabbit Monoclonal FCM 10200-R037
    Anti-DC-SIGN Antibody Rabbit Monoclonal ELISA(Det) 10200-R059
    Anti-DC-SIGN Antibody (APC) Mouse Monoclonal FCM 10200-MM01-A
    Anti-DC-SIGN Antibody (APC) Rabbit Monoclonal FCM 10200-R037-A
    Anti-DC-SIGN Antibody (PE) Rabbit Monoclonal FCM 10200-R037-P
    Anti-DC-SIGN Antibody Rabbit Polyclonal ELISA 10200-RP01
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