- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
>Cytokine & Cytokine Receptor
Cytokine & Cytokine Receptor
Cytokine is a general name; other names are defined based on their presumed function, cell of secretion, or target of action. More about What are Cytokines.
The cytokine superfamily includes interleukins, chemokines, colony-stimulating factors, interferons, and the transforming growth factors and tumor necrosis factor familes. More about Cytokine Families.
Cytokines are secreted by numerous cells. The secretion of cytokines and chemokines from cells is a fundamental response to injury and infection in the body. More about Cytokine Production.
Cytokines function as intercellular messengers that evoke particular biological activities by binding to a receptor on a responsive target cell. More about cytokine function.
Cytokines act on their target cells by binding specific membrane receptors. Many cell functions are regulated by members of the cytokine receptor superfamily. More about Cytokine Receptor.
Cytokine signaling via Jak-Stat pathways regulates all cell types involved in the initiation, propagation, and resolution of inflammation. More about Cytokine Signaling.
Cytokines may act on the cells that secrete them (autocrine action), on nearby cells (paracrine action), or in some instances on distant cells (endocrine action). More about Cytokine Network.
Over-secretion of cytokines can trigger a dangerous syndrome known as a cytokine storm. Cytokine storms also were the main cause of death in the 1918 "Spanish Flu" pandemic. More about Cytokine Storm.
Therapeutic targeting of cytokine pathways promises great hope for patients suffering from chronic diseases such as rheumatoid arthritis. More about Cytokine Therapy.
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During infection, inflammatory cytokines induce regulated changes in the host's internal milieu that create a hostile environment to an invading pathogen. More about Inflammatory Cytokines.
Overexpression of some special cytokines has detrimental cellular effects that include stimulating proliferation and angiogenesis. More about Cytokines in Angiogenesis.
- Cannon JG (2000). Inflammatory Cytokines in Nonpathological States. News Physiol Sci. 15: 298-303.
- Howlett M, et al. (2009) Cytokine signalling via gp130 in gastric cancer. Biochim Biophys Acta. 1793(11):1623-33.
- Desai D, et al. (2009) Cytokine and anti-cytokine therapy in asthma: ready for the clinic? Clin Exp Immunol. 158(1):10-9.
- Kunz M, et al. (2009) Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity. Mediators Inflamm. 2009:979258.
- Anne K, et al. (1998) Cytokines: Principles and prospects. Immunology and Cell Biology. 76, 300–317.