Cytokine & Cytokine Receptor

What are Cytokines

Cytokine is a general name; other names are defined based on their presumed function, cell of secretion, or target of action. More about What are Cytokines.

Cytokine Families

The cytokine superfamily includes interleukins, chemokines, colony-stimulating factors, interferons, and the transforming growth factors and tumor necrosis factor familes. More about Cytokine Families.

Cytokine Production

Cytokines are secreted by numerous cells. The secretion of cytokines and chemokines from cells is a fundamental response to injury and infection in the body. More about Cytokine Production.

Cytokine Function

Cytokines function as intercellular messengers that evoke particular biological activities by binding to a receptor on a responsive target cell. More about cytokine function.

Cytokine Receptor

Cytokines act on their target cells by binding specific membrane receptors. Many cell functions are regulated by members of the cytokine receptor superfamily. More about Cytokine Receptor.

Cytokine Signaling

Cytokine signaling via Jak-Stat pathways regulates all cell types involved in the initiation, propagation, and resolution of inflammation. More about Cytokine Signaling.

Cytokine Network

Cytokines may act on the cells that secrete them (autocrine action), on nearby cells (paracrine action), or in some instances on distant cells (endocrine action). More about Cytokine Network.

Cytokine Storm

Over-secretion of cytokines can trigger a dangerous syndrome known as a cytokine storm. Cytokine storms also were the main cause of death in the 1918 "Spanish Flu" pandemic. More about Cytokine Storm.

Cytokine Products

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• Cytokine Proteins (560+)
• Cytokine Antibodies (410+)
• Cytokine ELISA Kits (30+)
• Cytokine cDNA Clones (730+)

Browse by molecular

Chemokine & Receptor

Interleukin & Receptor

Interleukin-1 Family

Interleukin-6 Family

Interleukin-10 Family

Interleukin-12 Family

Interleukin-17 Family

Others

CSF & Receptor

Ohter Cytokines

TNF & Receptor

TGF-beta Superfamily

Activin/Inhibin

BMP Family

GDF Family

GDNF Family

TGF-beta Family

Others

Interferon & receptor

 

 

Cytokine Therapy

Therapeutic targeting of cytokine pathways promises great hope for patients suffering from chronic diseases such as rheumatoid arthritis. More about Cytokine Therapy.

Inflammatory Cytokines

During infection, inflammatory cytokines induce regulated changes in the host's internal milieu that create a hostile environment to an invading pathogen. More about Inflammatory Cytokines.

Cytokines in Angiogenesis

Overexpression of some special cytokines has detrimental cellular effects that include stimulating proliferation and angiogenesis. More about Cytokines in Angiogenesis.

Cytokine & Receptor Related Studies

1. Cannon JG (2000). Inflammatory Cytokines in Nonpathological States. News Physiol Sci. 15: 298-303.
2. Howlett M, et al. (2009) Cytokine signalling via gp130 in gastric cancer. Biochim Biophys Acta. 1793(11):1623-33.
3. Desai D, et al. (2009) Cytokine and anti-cytokine therapy in asthma: ready for the clinic? Clin Exp Immunol. 158(1):10-9.
4. Kunz M, et al. (2009) Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity. Mediators Inflamm. 2009:979258.
5. Anne K, et al. (1998) Cytokines: Principles and prospects. Immunology and Cell Biology. 76, 300–317.