Cystatin SA (CST2)

Thiol protease inhibitor.

Cystatin SA (CST2) Related Areas

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Cystatin>>Cystatin SA/CST2

Cancer>>Angiogenesis>>Cystatin>>Cystatin SA/CST2

Cystatin SA (CST2) Alternative Names

Cystatin SA, CST2, cystatin 2, cystatin S5, cystatin-2, cystatin-S5, cystatin-SA, MGC71924 [Homo sapiens]

Summaries for Cystatin SA (CST2)

Entrez Gene summary for Cystatin SA (CST2):

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma.

OMIM - description for Cystatin SA (CST2):

By screening a submandibular gland cDNA library with oligonucleotides derived from the sequence of purified cystatin S (CST4; 123857), Saitoh et al. (1987) isolated a CST2 cDNA. The CST2 precursor protein has 141 amino acids, including a 20-amino acid N-terminal signal sequence. By RNase protection assay of 23 human tissues, Dickinson et al. (2002) found that CST2 was expressed only in submandibular gland and parotid gland.

Wikipedia summary for Cystatin SA (CST2):

Cystatin-SA is a protein that in humans is encoded by the CST2 gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma

Human Cystatin SA (CST2) Protein General Information

 

• Protein names: Recommended name: Cystatin-SA
• Sequence length: 141 AA.
• Domain: Signal
• Sequence similarities: Belongs to the cystatin family.
• Mass spectrometry: Molecular mass is 14336.9856±0.0158 Da from positions 21 - 141. Determined by ESI.
• Subcellular location: Secreted
• Tissue specificity: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in submandibular gland and parotid gland.

General information above from UniProt

Function for Cystatin SA (CST2) Protein

UniProtKB:

Thiol protease inhibitor.

Genatlas:

• cysteine proteinase inhibitor
• Cystatin SA (CST2) induce interleukin-6 expression via cell surface molecules in gingival fibroblasts

Homology for human Cystatin SA (CST2)

• paralog to CST1,CST4