Anti-CST6 Antibody

Cat: 10438-R034
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All CST6 Reagents
Anti-CST6 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-CST6 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CST6
Immunogen
Recombinant Human Cystatin E / CST6 protein (Catalog#10438-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human Cystatin E / CST6 (rh Cystatin E / CST6; Catalog#10438-H08H; NP_001314.1; Met 1-Met 149).
Source
Monoclonal Rabbit IgG Clone #034
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CST6 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

CST6 Background Information

Cystatin E/M, also referred to as CST6, is a member of type 2 cysteine proteinase inhibitors of the cystatin superfamily, and inhibits papain and cathepsin B. Cystatin E is a low molecular mass secreted protein existing in both a glycosylated (17 kDa) and an unglycosylated (14 kDa) form, with two characteristic intrachain disulfide bridges. Expression of cystatin M/E is found to be restricted to the epidermis, more specifically in the stratum granulosum, sweat glands, sebaceous glands, and the hair follicles. In addition to its function as a cysteine protease inhibitor, cystatin M/E also serves as a target for cross-linking by transglutaminases. Accordingly, cystatin M/E was suggested to be involved in barrier formation and maintenance. Furthermore, studies have revealed that cystatin M/E is frequently epigenetically inactivated during breast carcinogenesis, and thus be regarded as a candidate of tumour suppressor gene.

Full Name
cystatin E/M
References
  • Ritonja A., et al.,(1985), Amino acid sequence of the intracellular cysteine proteinase inhibitor cystatin B from human liver. Biochem. Biophys. Res. Commun. 131:1187-1192.
  • Pennacchio L.A., et al., (1996), Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1).Science 271:1731-1734.
  • Ghaemmaghami S., et al.,(2003), Global analysis of protein expression in yeast.Nature 425:737-741.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CST6 Antibody Rabbit Polyclonal ELISA,IHC-P 50916-RP02
    Anti-CST6 Antibody Rabbit Polyclonal ELISA 50916-RP01
    Anti-CST6 Antibody Rabbit Monoclonal ELISA 50916-R037
    Anti-CST6 Antibody Mouse Monoclonal IHC-P 10438-MM17
    Anti-CST6 Antibody Mouse Monoclonal ELISA,ELISA(Det) 10438-MM02
    Anti-CST6 Antibody Rabbit Monoclonal ELISA(Cap) 10438-R022
    Anti-CST6 Antibody Mouse Monoclonal ELISA 10438-MM19
    Anti-CST6 Antibody Rabbit Polyclonal ELISA 10438-RP01
    Anti-CST6 Antibody Rabbit Polyclonal ELISA 10438-RP02
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