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Cystatin E / CST6 Antibody, Mouse MAb

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Human Cystatin E/CST6 Antibody Product Information
Immunogen:Recombinant Human CST6 protein (Catalog#10438-H08H)
Clone ID:4E7C10B7
Ig Type:Mouse IgG2a
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cystatin-M / CST6 (rh Cystatin-M; Catalog#10438-H08H; NP_001314.1; Met 1-Met 149). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Human Cystatin E/CST6 Antibody Usage Guide
Specificity:Human Cystatin-M / Cystatin-E / CST6
No cross-reactivity with Human cell lysate (293 cell line) in WB and ELISA

ELISA: 0.5-1.0 μg/mL

This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human CST6. The detection limit for Human CST6 is 0.31 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other Cystatin E/CST6 Antibody Products
Cystatin E / CST6 Background

Cystatin E/M, also referred to as CST6, is a member of type 2 cysteine proteinase inhibitors of the cystatin superfamily, and inhibits papain and cathepsin B. Cystatin E is a low molecular mass secreted protein existing in both a glycosylated (17 kDa) and an unglycosylated (14 kDa) form, with two characteristic intrachain disulfide bridges. Expression of cystatin M/E is found to be restricted to the epidermis, more specifically in the stratum granulosum, sweat glands, sebaceous glands, and the hair follicles. In addition to its function as a cysteine protease inhibitor, cystatin M/E also serves as a target for cross-linking by transglutaminases. Accordingly, cystatin M/E was suggested to be involved in barrier formation and maintenance. Furthermore, studies have revealed that cystatin M/E is frequently epigenetically inactivated during breast carcinogenesis, and thus be regarded as a candidate of tumour suppressor gene.

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