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Cystatin E / CST6 Antibody, Mouse MAb

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    Human Cystatin E/CST6 Antibody Product Information
    Immunogen:Recombinant Human CST6 protein (Catalog#10438-H08H)
    Clone ID:4E7C10B7
    Ig Type:Mouse IgG2a
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cystatin-M / CST6 (rh Cystatin-M; Catalog#10438-H08H; NP_001314.1; Met 1-Met 149). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
    Other Cystatin E/CST6 Antibody Products
    Cystatin E / CST6 Background

    Cystatin E/M, also referred to as CST6, is a member of type 2 cysteine proteinase inhibitors of the cystatin superfamily, and inhibits papain and cathepsin B. Cystatin E is a low molecular mass secreted protein existing in both a glycosylated (17 kDa) and an unglycosylated (14 kDa) form, with two characteristic intrachain disulfide bridges. Expression of cystatin M/E is found to be restricted to the epidermis, more specifically in the stratum granulosum, sweat glands, sebaceous glands, and the hair follicles. In addition to its function as a cysteine protease inhibitor, cystatin M/E also serves as a target for cross-linking by transglutaminases. Accordingly, cystatin M/E was suggested to be involved in barrier formation and maintenance. Furthermore, studies have revealed that cystatin M/E is frequently epigenetically inactivated during breast carcinogenesis, and thus be regarded as a candidate of tumour suppressor gene.

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    Catalog: 10438-MM02-200
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    Datasheet & Documentation

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"