Cystatin C Protein & Antibody (CST3)

Cystatin C

Cystatin C Protein Products

Cystatin C Protein Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Cystatin C/CST3	Human	Cystatin C / CST3 Protein, Recombinant	10439-H08H
Cystatin C/CST3	Mouse	Cystatin C / CST3 Protein, Recombinant	50239-M08H
Cystatin C/CST3	Rat	Cystatin C / CST3 Protein, Recombinant	80040-R08H

  10439-H08H:  The IC₅₀ value is < 12 nM . Measured by its ability to inhibit papain cleavage of a fluorogenic peptide substrate Z-FR-AMC,R&D Systems, Catalog # ES009.

  50239-M08H:  The IC₅₀ value is < 13 nM . Measured by its ability to inhibit papain cleavage of a fluorogenic peptide substrate Z-FR-AMC,R&D Systems, Catalog # ES009.

Cystatin C Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Cystatin C/CST3	ELISA	Cystatin C / CST3 Antibody	10439-R001
Human Cystatin C/CST3	WB, ELISA	Cystatin C / CST3 Antibody	10439-RP01
Human Cystatin C/CST3	WB, ELISA	Cystatin C / CST3 Antibody (Antigen Affinity Purified)	10439-RP02
Mouse Cystatin C/CST3	WB, ELISA	Cystatin C / CST3 Antibody, Rabbit PAb	50239-RP01
Mouse Cystatin C/CST3	WB, ELISA	Cystatin C / CST3 Antibody, Rabbit PAb (Antigen Affinity Purified)	50239-RP02
Rat Cystatin C/CST3	WB, ELISA	Cystatin C / CST3 Antibody (Antigen Affinity Purified)	80040-RP02

Cystatin C Protein cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Cystatin C/CST3	Human	Homo sapiens Cystatin C / CST3 cDNA Clone(NM_000099.2)	HG10439-M
Cystatin C/CST3	Mouse	Mus musculus Cystatin C / CST3 cDNA Clone	MG50239-M
Cystatin C/CST3	Rat	Rattus norvegicus Cystatin C / CST3 cDNA Clone	RG80040-M

Cystatin C Protein Related Areas

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Cystatin>>Cystatin C/CST3

Cancer>>Angiogenesis>>Cystatin>>Cystatin C/CST3

Cystatin C Protein Alternative Names

Cystatin C, CST3, ARMD11, MGC117328 [Homo sapiens]

Cystatin C, Cst3, CysC, RP23-250M11.9 [Mus musculus]

Cystatin C Protein Related Products

Protein Products

Molecule	Species	Description
Cystatin A/CSTA/Stefin A	Human	Cystatin A / CSTA / Stefin A Protein, Recombinant
Cystatin B/CSTB/Stefin B	Human	Cystatin B / CSTB / Stefin B Protein, Recombinant
Cystatin SN/CST1	Human	Cystatin SN / CST1 Protein, Recombinant
Cystatin D/CST5	Human	Cystatin D / CST5 Protein, Recombinant
Cystatin E/CST6	Human	Cystatin E / CST6 Protein, Recombinant
Cystatin F/CST7	Human	Cystatin F / CST7 / Fc Protien, Recombinant
Cystatin F/CST7	Human	Cystatin F / CST7 Protien, Recombinant
Cystatin F/CST7	Human	Cystatin F / CST7 Protein, Recombinant
Cystatin S/CST4	Human	Cystatin S / CST4 Protein, Recombinant
Cystatin SA/CST2	Human	Cystatin SA / CST2 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human Cystatin SA/CST2	WB, ELISA	Cystatin SA / CST2 Antibody, Rabbit PAb
Human Cystatin SA/CST2	WB, ELISA	Cystatin SA / CST2 Antibody, Rabbit PAb (Antigen Affinity Purified)
Human Cystatin S/CST4	WB, ELISA	Cystatin S / CST4 Antibody, Rabbit PAb
Human Cystatin S/CST4	WB, ELISA	Cystatin S / CST4 Antibody, Rabbit PAb (Antigen Affinity Purified)
Human Cystatin E/CST6	ELISA	Cystatin E / CST6 Antibody, Mouse MAb
Human Cystatin E/CST6	WB, ELISA	Cystatin E / CST6 Rabbit Polyclonal Antibody
Human Cystatin E/CST6	WB, ELISA	Cystatin E/ CST6 Antibody, Rabbit PAb (Antigen Affinity Purified)
Human Cystatin F/CST7	WB	Cystatin F / CST7 Antibody, Mouse MAb
Human Cystatin F/CST7	ELISA	Cystatin F / CST7 Antibody, Mouse MAb
Human Cystatin F/CST7	WB, ELISA	Cystatin F / CST7 Antibody, Rabbit PAb
Human Cystatin F/CST7	WB, ELISA	Cystatin F / CST7 Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
Cystatin A/CSTA/Stefin A	Human	Human Cystatin-A / CSTA / Stefin A cDNA Clone / ORF Clone
Cystatin B/CSTB/Stefin B	Human	Human Cystatin B / CSTB / Stefin B cDNA Clone / ORF Clone
Cystatin SN/CST1	Human	Human Cystatin SN / CST1 cDNA Clone / ORF Clone
Cystatin D/CST5	Human	Homo sapiens Cystatin D / CST5 cDNA Clone(NM_001900.4)
Cystatin E/CST6	Human	Homo sapiens Cystatin E / CST6 cDNA Clone(NM_001323.2)
Cystatin F/CST7	Human	Homo sapiens Cystatin F / CST7 cDNA Clone(NM_003650.2)
Cystatin F/CST7	Mouse	Mus musculus Cystatin F / CST7 cDNA Clone
Cystatin S/CST4	Human	Homo sapiens Cystatin S / CST4 cDNA Clone
Cystatin SA/CST2	Human	Homo sapiens Cystatin SA / CST2 cDNA Clone

Cystatin C Background

Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal function, particularly to detect small reductions in glomerular filtration rate. The mature, active form of human cystatin C is a single non-glycosylated polypeptide chain consisting of 120 amino acid residues, with a molecular mass of 13,343-13,359 Da, and containing four characteristic disulfide-paired cysteine residues. Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of Cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. In almost all the clinical studies, Cystatin C demonstrated a better diagnostic accuracy than serum creatinine in discriminating normal from impaired kidney function, but controversial results have been obtained by comparing this protein with other indices of kidney disease, especially serum creatinine-based equations, such as early atherosclerosis, Alzheimer's dementia, vascular aneurysms, hyperhomocysteinaemia and other neurodegenerative diseases. Cystatin C could be a useful clinical tool to identify HIV-infected persons. In addition, its expression is up-regulated in malignance of certain tumor progression.

Cystatin C Related Studies

1. Mares J, et al. (2003) Use of cystatin C determination in clinical diagnostics. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 147(2): 177-80.
2. Mussap M, et al. (2004) Biochemistry and clinical role of human cystatin C. Crit Rev Clin Lab Sci. 41(5-6): 467-550.
3. Séronie-Vivien S, et al. (2008) Cystatin C: current position and future prospects. Clin Chem Lab Med. 46(12): 1664-86.
4. Taglieri N, et al. (2009) Cystatin C and cardiovascular risk. Clin Chem. 55(11): 1932-43.