|Catalog||Size (Price)||Quantity||In Stock||Operation||Other Information|
Cystatin C / CST3 Antibody Datasheet
|Order or Inquire for Cystatin C / CST3 Antibody product||Quality antibodies||Antibody production services|
|Detection limit is 0.00975 ng/well in ELISA|
Cystatin C / CST3 Antibody Product Information
Recombinant Human Cystatin C / CST3 protein (Catalog#10439-H08H)
|Antibody Type :||Rabbit Polyclonal Antibody ( Antibody Purification Platform )|
|Ig Type :||
|Formulation :||0.2 μm filtered solution in PBS with 5% trehalose|
Produced in rabbits immunized with purified, recombinant Human Cystatin C / CST3 (rh Cystatin C / CST3; Catalog#10439-H08H; NP_000090.1; Met 1-Ala 146). Total IgG was purified by Protein A affinity chromatography.
Cystatin C / CST3 Antibody Usage Guide
Human Cystatin C / CST3
|Western blot :||This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human CST3 in WB.|
|Direct ELISA :||This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human CST3. The detection limit for Human CST3 is approximately 0.00975 ng/well.|
|Storage :||This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Cystatin C / CST3 Antibody Related Products & Topics
Cystatin C / CST3 Antibody Background
Cystatin-C / CST3 is a secreted type 2 cysteine proteinase inhibitors of the cystatin superfamily, and exerts actions on a variety of cysteine proteases including papain and Cathepsins B, H, K, L and S. As the most abundant extracellular inhibitor of cysteine proteases, Cystatin-C encoded by a housekeeping gene is found ubiquitously in all organs and biological fluids at high concentration levels. It has been shown that cystatin-C binds amyloid-beta and reduces cerebral amyloid-beta deposition or inhibits its fibril formation in an APP-transgenic mouse model. Thus, a point mutation in this gene (Leu 68 to Gln) hsa been associated with a severe hereditary form of amyloid angiopathy. Studies have also investigated cystatin-C as a marker of kidney function and thyroid dysfunction prior to creatinine, and could be a useful clinical tool to identify HIV-infected persons. In addition, cystatin-C expression is up-regulated in malignance of certain tumor progression.
- Janowski, R. et al., 2001, Nat. Struct. Biol. 8: 316-320.
- Kos, J. et al., 1998, Clin.Chem. 44: 2556-2557.
- Fricker, M. et al., 2003, Kidney. Int. 63: 1944-1947.
- Kaeser, S.A. et al., 2007, Nat. Genet. 39: 1437-1439.
- Odden, M.C. et al., 2007, Arch. Intern. Med. 167: 2213-2219.
Cystatin C(CST3) related areas, pathways, and other information