Anti-Cystatin B Antibody

Cat: 10435-RP02

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All Cystatin B Reagents
Anti-Cystatin B Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Cystatin B Antibody
Validated applications
Species reactivity
Reacts with: Human
Human Cystatin B
Recombinant Human Cystatin B / CSTB protein (Catalog#10435-H07E)
Produced in rabbits immunized with purified, recombinant Human Cystatin B / CSTB (rh Cystatin B / CSTB; Catalog#10435-H07E; P04080; Met 2-Phe 98). Cystatin B / CSTB specific IgG was purified by Human Cystatin B / CSTB affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Cystatin B Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Cystatin B Antibody (Rabbit Polyclonal antibody) Images
Human Cystatin B / CSTB Western blot (WB) 13217

Anti-CSTB rabbit polyclonal antibody at 1:500 dilution

Lane A: MCF7 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:12 kDa

Observed band size:12 kDa

Anti-Cystatin B Antibody Alternative Names
Anti-CST6 Antibody;Anti-EPM1 Antibody;Anti-EPM1A Antibody;Anti-PME Antibody;Anti-STFB Antibody;Anti-ULD Antibody
Cystatin B Background Information

Cystatin-B, also known as CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB and CST6, is a cytoplasm and nucleus protein which belongs to the cystatin family. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes. Defects in Cystatin-B / CSTB are the cause of progressive myoclonic epilepsy type 1 (EPM1) which is an autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures. The cystatins are a family of cysteine protease inhibitors with homology to chicken cystatin. Cystatins are physiological inhibitors of cysteine proteinases which are widely distributed in human tissues and fluids. Cystatins typically comprise about 115 amino acids, are largely acidic, contain four conserved cysteine residues known to form two disulfide bonds. Cystatins may be glycosylated and / or phosphorylated, with similarity to fetuins, kininogens, stefins, histidine-rich glycoproteins and cystatin-related proteins. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired inhibitory activity. Cystatins mainly inhibit peptidases belonging to peptidase families C1 (papain family) and C13 (legumain family).

Full Name
cystatin B (stefin B)
  • Ritonja A., et al.,(1985), Amino acid sequence of the intracellular cysteine proteinase inhibitor cystatin B from human liver. Biochem. Biophys. Res. Commun. 131:1187-1192.
  • Pennacchio L.A., et al., (1996), Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1).Science 271:1731-1734.
  • Hattori M., et al.,(2000), The DNA sequence of human chromosome 21.Nature 405:311-319.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Cystatin B Antibody Mouse Monoclonal ELISA 10435-MM06
    Anti-Cystatin B Antibody Rabbit Polyclonal ELISA 10435-RP01
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