|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rhesus TGFBR2 ORF mammalian expression plasmid, C-GFPSpark tag||CG90063-ACG|
|Rhesus TGFBR2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||CG90063-ACR|
|Rhesus TGFBR2 ORF mammalian expression plasmid, C-Flag tag||CG90063-CF|
|Rhesus TGFBR2 ORF mammalian expression plasmid, C-His tag||CG90063-CH|
|Rhesus TGFBR2 ORF mammalian expression plasmid, C-Myc tag||CG90063-CM|
|Rhesus TGFBR2 ORF mammalian expression plasmid, C-HA tag||CG90063-CY|
|Rhesus TGFBR2 Gene cDNA clone plasmid||CG90063-G|
|Rhesus TGFBR2 ORF mammalian expression plasmid, N-Flag tag||CG90063-NF|
|Rhesus TGFBR2 ORF mammalian expression plasmid, N-His tag||CG90063-NH|
|Rhesus TGFBR2 ORF mammalian expression plasmid, N-Myc tag||CG90063-NM|
|Rhesus TGFBR2 ORF mammalian expression plasmid, N-HA tag||CG90063-NY|
|Rhesus TGFBR2 natural ORF mammalian expression plasmid||CG90063-UT|
|Learn more about expression Vectors|
TGFBR2 is member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised by a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets. TGFBR2 has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is increased in oral squamous cell carcinoma cells. Its expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity.