CK2 alpha cDNA ORF Clone, Rhesus, C-His tag

Cat: CG90444-CH
Contact us:
+86-400-890-9989
order@sinobiological.com
Distributors
All CK2 alpha Reagents
CRO Services
Product recommended

All CK2 alpha Reagents
CK2 alpha cDNA ORF Clone, Rhesus, C-His tag General Information
Gene
Species
Rhesus
NCBI Ref Seq
RefSeq ORF Size
1176 bp
Description
Full length Clone DNA of Rhesus casein kinase 2, alpha 1 polypeptide with C terminal His tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-His
Tag Sequence
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

CK2 alpha Background Information

Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser / Thr protein kinase family and CK2 subfamily. Casein kinase II (CSNK2A1) is a serine / threonine protein kinase that phosphorylates acidic proteins such as casein. This kinase is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. Casein kinase II (CSNK2A1) is a constitutively active, ubiquitously expressed serine / threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CSNK2A1 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CSNK2A1, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CSNK2A1 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CSNK2A1 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via th phosphorylation of Akt.

Full Name
casein kinase 2, alpha 1 polypeptide
References
  • Schlpfer J, et al. (1997) A radiation hybrid framework map of bovine chromosome 13. Chromosome Res. 5(8): 511-9.
  • Wirkner U, et al. (1994) The human gene (CSNK2A1) coding for the casein kinase II subunit alpha is located on chromosome 20 and contains tandemly arranged Alu repeats. Genomics. 19(2): 257-65.
  • Wirkner U, et al. (1998) Genomic organization and promoter identification of the human protein kinase CK2 catalytic subunit alpha (CSNK2A1). Genomics. 48(1): 71-8.
  • CK2 alpha cDNA ORF Clone, Rhesus, Related Products

    Product Name Catalog#(PDF)
    CK2 alpha cDNA ORF Clone in Cloning Vector, Rhesus CG90444-G
    CK2 alpha cDNA ORF Clone, Rhesus, untagged CG90444-UT
    CK2 alpha cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90444-ACG
    CK2 alpha Lentiviral cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90444-ACGLN
    CK2 alpha cDNA ORF Clone, Rhesus, N-GFPSpark® tag CG90444-ANG
    CK2 alpha cDNA ORF Clone, Rhesus, C-OFPSpark® tag CG90444-ACR
    CK2 alpha cDNA ORF Clone, Rhesus, N-OFPSpark® tag CG90444-ANR
    CK2 alpha cDNA ORF Clone, Rhesus, C-DDK (Flag®) tag CG90444-CF
    CK2 alpha cDNA ORF Clone, Rhesus, N-DDK (Flag®) tag CG90444-NF
    CK2 alpha cDNA ORF Clone, Rhesus, N-His tag CG90444-NH
    CK2 alpha cDNA ORF Clone, Rhesus, C-HA tag CG90444-CY
    CK2 alpha cDNA ORF Clone, Rhesus, N-HA tag CG90444-NY
    CK2 alpha cDNA ORF Clone, Rhesus, C-Myc tag CG90444-CM
    CK2 alpha cDNA ORF Clone, Rhesus, N-Myc tag CG90444-NM

    CK2 alpha cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    CK2 alpha cDNA ORF Clone in Cloning Vector, Rat RG83569-U
    CK2 alpha Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG83569-ACGLN

    CK2 alpha cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    CK2 alpha cDNA ORF Clone in Cloning Vector, Mouse MG50818-G
    CK2 alpha cDNA ORF Clone, Mouse, untagged MG50818-UT
    CK2 alpha Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50818-ACGLN
    CK2 alpha cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50818-ACG
    CK2 alpha cDNA ORF Clone, Mouse, N-GFPSpark® tag MG50818-ANG
    CK2 alpha cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50818-ACR
    CK2 alpha cDNA ORF Clone, Mouse, N-OFPSpark® tag MG50818-ANR
    CK2 alpha cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50818-CF
    CK2 alpha cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50818-NF
    CK2 alpha cDNA ORF Clone, Mouse, C-His tag MG50818-CH
    CK2 alpha cDNA ORF Clone, Mouse, N-His tag MG50818-NH
    CK2 alpha cDNA ORF Clone, Mouse, C-HA tag MG50818-CY
    CK2 alpha cDNA ORF Clone, Mouse, N-HA tag MG50818-NY
    CK2 alpha cDNA ORF Clone, Mouse, C-Myc tag MG50818-CM
    CK2 alpha cDNA ORF Clone, Mouse, N-Myc tag MG50818-NM
    CK2 alpha qPCR Primer Pairs, Mouse MP200789

    CK2 alpha cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    CK2 alpha cDNA ORF Clone in Cloning Vector, Human HG10630-G
    CK2 alpha cDNA ORF Clone, Human, untagged HG10630-UT
    CK2 alpha Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10630-ACGLN
    CK2 alpha cDNA ORF Clone, Human, C-GFPSpark® tag HG10630-ACG
    CK2 alpha cDNA ORF Clone, Human, N-GFPSpark® tag HG10630-ANG
    CK2 alpha cDNA ORF Clone, Human, C-OFPSpark® tag HG10630-ACR
    CK2 alpha cDNA ORF Clone, Human, N-OFPSpark® tag HG10630-ANR
    CK2 alpha cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10630-CF
    CK2 alpha cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10630-NF
    CK2 alpha cDNA ORF Clone, Human, C-His tag HG10630-CH
    CK2 alpha cDNA ORF Clone, Human, N-His tag HG10630-NH
    CK2 alpha cDNA ORF Clone, Human, C-HA tag HG10630-CY
    CK2 alpha cDNA ORF Clone, Human, N-HA tag HG10630-NY
    CK2 alpha cDNA ORF Clone, Human, C-Myc tag HG10630-CM
    CK2 alpha cDNA ORF Clone, Human, N-Myc tag HG10630-NM
    CK2 alpha qPCR Primer Pairs, Human HP100606
    info info
    添加购物车成功! 添加购物车失败!