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TMEM100 Protein, Antibody, ELISA Kit, cDNA Clone

TMEM100 Related Areas

TMEM100 Related Pathways

TMEM100 Related Product

    TMEM100 Background

    Gene Summary: The protein encoded by PPIB gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]
    General information above from NCBI
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0).
    Enzyme regulation: Cyclosporin A (CsA) inhibits CYPB.
    Subunit structure: Interacts with DYM.
    Subcellular location: Membrane; Multi-pass membrane protein (Potential).C
    Involvement in disease: Osteogenesis imperfecta 9 (OI9) [MIM:259440]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild form
    Sequence similarities: Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
    Contains 1 PPIase cyclophilin-type domain.
    General information above from UniProt

    TMEM100 Altermative Names

    TMEM100 Related Studies

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