Gene Summary: The protein encoded by PPIB gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]General information above from NCBI
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation: Cyclosporin A (CsA) inhibits CYPB.
Subunit structure: Interacts with DYM.
Subcellular location: Membrane; Multi-pass membrane protein (Potential).C
Involvement in disease: Osteogenesis imperfecta 9 (OI9) [MIM:259440]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild form
Sequence similarities: Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
Contains 1 PPIase cyclophilin-type domain.
General information above from UniProt