All Cyclophilin A reagents are produced in house and quality controlled, including 3 Cyclophilin A Antibody, 40 Cyclophilin A Gene, 1 Cyclophilin A IPKit, 2 Cyclophilin A Protein, 3 Cyclophilin A qPCR. All Cyclophilin A reagents are ready to use.
Recombinant Cyclophilin A proteins are expressed by E. coli with fusion tags as C-His.
Cyclophilin Aantibodies are validated with different applications, which are ELISA, WB, IP.
Cyclophilin AcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Cyclophilin A of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Peptidyl-prolyl cis-trans isomerase A, also known as PPIase A, Rotamase A, Cyclophilin A, Cyclosporin A-binding protein, PPIA and CYPA, is a cytoplasm protein which belongs to the cyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins (CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. These molecules exhibit peptidyl-prolyl isomerase activity, suggesting that they influence the conformation of proteins in cells. PPIA / Cyclophilin A accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIA / Cyclophilin A is secreted by vascular smooth muscle cells in response to inflammatory stimuli, and could thus contribute to atherosclerosis. It is not essential for mammalian cell viability. PPIA / Cyclophilin A can interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions.