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Cyclin E1/CCNE1  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Baculovirus-Insect Cells  
10902-H07B-50
10902-H07B-20
50 µg 
20 µg 
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Expression host: Baculovirus-Insect Cells  
10902-HNCB-20
10902-HNCB-100
20 µg 
100 µg 
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Expression host: Baculovirus-Insect Cells  
10902-H20B-20
10902-H20B-100
20 µg 
100 µg 
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Expression host: Baculovirus-Insect Cells  
50896-M20B-20
50896-M20B-100
20 µg 
100 µg 
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  • Slide 1

Cyclin E1/CCNE1 Related Area

Cyclin E1/CCNE1 Related Pathways

Cyclin E1/CCNE1 Summary & Protein Information

Cyclin E1/CCNE1 Background

Gene Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
General information above from NCBI
Subunit structure: Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation. {ECO:0000250, ECO:0000269|PubMed:15178429, ECO:0000269|PubMed:15660127, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:21952639}.
Subcellular location: Nucleus {ECO:0000269|PubMed:7739542}.
Tissue specificity: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. {ECO:0000269|PubMed:9840943}.
Post-translational: Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7. {ECO:0000269|PubMed:14536078, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:21952639, ECO:0000269|PubMed:8861947}.; Ubiquitinated by UHRF2; appears to occur independently of phosphorylation. {ECO:0000269|PubMed:21952639}.
Sequence similarity: Belongs to the cyclin family. Cyclin E subfamily. {ECO:0000305}.
General information above from UniProt

Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that bind, activate, and provide substrate for its associated cyclin-dependent kinase2 (CDK2), whose activity is essential for cell cycle G1 / S transition. Over expression of this encoding gene has been found in many tumors, which results in chromosome instability and by extension, induce tumorigenesis. This protein was also found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. In general, cyclin E1, as an activator of phospho-CDK2 (pCDK2), is important for cell cycle progression and is frequently overexpressed in cancer cells.

Cyclin E1/CCNE1 Alternative Name

CCNE, [homo-sapiens]
CCNE,CCNE1,Cyclin E1, [human]
AW538188,Ccne1,Cyclin E1, [mouse]
CycE1,AW538188, [mus-musculus]

Cyclin E1/CCNE1 Related Studies

  • Honda R, et al. (2005) The structure of cyclin E1 / CDK2: implications for CDK2 activation and CDK2-independent roles. The EMBO Journal. 24: 452-63.
  • Geng Y, et al. (2007) Kinase-Independent Function of Cyclin E. 25(1): 127-39.
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