Cyclin E1 Protein & Antibody (CCNE1)

Cyclin E1 Products

Cyclin E1 Protein, Recombinant

Molecule	Species	Description	Cat. No
Cyclin E1/CCNE1	Human	Cyclin E1/CCNE1 Protein, Recombinant	10902-H07B
Cyclin E1/CCNE1	Human	Cyclin E1/CCNE1 Protein, Recombinant， with GST Tag	10902-H20B

Cyclin E1 Antibody

Molecule	Application	Description	Cat. No
Human Cyclin E1/CCNE1	WB, ELISA	Cyclin E1/CCNE1 Antibody, Rabbit PAb	10902-RP01
Human Cyclin E1/CCNE1	WB, ELISA	Cyclin E1/CCNE1 Antibody, Rabbit PAb (Antigen Affinity Purified)	10902-RP02

Cyclin E1 cDNA Clone

Molecule	Species	Description	Cat. No
Cyclin E1/CCNE1	Human	Homo sapiens Cyclin E1/CCNE1 DNA cDNA Clone	HG10902-M
Cyclin E1/CCNE1	Mouse	Mouse Cyclin E1/CCNE1 cDNA Clone / ORF Clone	MG50896-G

Cyclin E1 Related Areas

Cancer>>Cell Cycle>>Cyclin>>Cyclin E1/CCNE1

Cyclin E1 Alternative Names

Cyclin E1, CCNE1, CCNE [Homo sapiens]

Cyclin E1, Ccne1, AW538188 [Mus musculus]

Cyclin E1 Background

Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that bind, activate, and provide substrate for its associated cyclin-dependent kinase2 (CDK2), whose activity is essential for cell cycle G1 / S transition. Over expression of this encoding gene has been found in many tumors, which results in chromosome instability and by extension, induce tumorigenesis. This protein was also found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. In general, cyclin E1, as an activator of phospho-CDK2 (pCDK2), is important for cell cycle progression and is frequently overexpressed in cancer cells.

Cyclin E1 Related Studies

1. Honda R, et al. (2005) The structure of cyclin E1 / CDK2: implications for CDK2 activation and CDK2-independent roles. The EMBO Journal. 24: 452-63.
2. Geng Y, et al. (2007) Kinase-Independent Function of Cyclin E. 25(1): 127-39.