Anti-Cyclin E Antibody

Cat: 10902-RP01
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All Cyclin E Reagents
Anti-Cyclin E Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Cyclin E Antibody
Validated applications
Species reactivity
Reacts with: Human
Human Cyclin E
Recombinant Human CCNE1 protein (Catalog#10902-H07B)
Produced in rabbits immunized with purified, recombinant Human CCNE1 (rh CCNE1 , Catalog#10902-H07B; NP_001229.1; Met 1-Ala 410). Total IgG was purified by Protein A affinity chromatography .
Polyclonal Rabbit IgG
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Cyclin E Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Cyclin E Antibody Alternative Names
Anti-CCNE Antibody
Cyclin E Background Information

Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that bind, activate, and provide substrate for its associated cyclin-dependent kinase2 (CDK2), whose activity is essential for cell cycle G1 / S transition. Over expression of this encoding gene has been found in many tumors, which results in chromosome instability and by extension, induce tumorigenesis. This protein was also found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. In general, cyclin E1, as an activator of phospho-CDK2 (pCDK2), is important for cell cycle progression and is frequently overexpressed in cancer cells.

Full Name
cyclin E1
  • Honda R, et al. (2005) The structure of cyclin E1 / CDK2: implications for CDK2 activation and CDK2-independent roles. The EMBO Journal. 24: 452-63.
  • Geng Y, et al. (2007) Kinase-Independent Function of Cyclin E. 25(1): 127-39.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Cyclin E Antibody Mouse Monoclonal ICC/IF,IF 10902-MM03
    Anti-Cyclin E Antibody Mouse Monoclonal IHC-P 10902-MM11
    Anti-Cyclin E Antibody Rabbit Polyclonal WB,ELISA,IHC-P 10902-RP02
    Anti-Cyclin E Antibody Mouse Monoclonal FCM,ICC/IF,IF 10902-MM03T
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