Cyclin A1 Protein & Antibody (CCNA1)

Cyclin A1 Products

Cyclin A1 Protein, Recombinant

Molecule	Species	Description	Cat. No
Cyclin A1/CCNA1	Human	Cyclin A1/CCNA1 Protein, Recombinant	11013-H07B

Cyclin A1 Antibody

Molecule	Application	Description	Cat. No
Human Cyclin A1/CCNA1	WB, ELISA	Cyclin A1/CCNA1 Antibody, Mouse MAb	11013-MM02

Cyclin A1 cDNA Clone

Molecule	Species	Description	Cat. No
Cyclin A1/CCNA1	Human	Homo sapiens Cyclin A1/CCNA1 cDNA Clone	HG11013-M

Cyclin A1 Related Areas

Cancer>>Cell Cycle>>Cyclin>>Cyclin A1/CCNA1

Cyclin A1 Alternative Names

CCNA1, cyclin-A1 [Homo sapiens]

Ccna1, MGC159139, cyclin-A1 [Mus musculus]

Cyclin A1 Background

Cyclin A1 is a member of the highly conserved cyclin family that is characterized by a dramatic periodicity in protein abundance, and belongs to the A-type cyclin subfamily. The mammalian A-type cyclin family consists of two members: cyclin A1 and cyclin A2. Different cyclins exhibit distinct expression. Cyclin A1 is expressed in mice exclusively in the germ cell lineage and high rate of cyclinA1 is found in human testis and certain myeloid leukaemia cells. Cyclin A1 is primarily function in the control of meiosis. It serves as regulator subunits binding to cyclin-dependent kinase 1 (Cdk1) and cyclin-dependent kinase 2 (Cdk2), which give two different kinase activities, one appearing in S phase, the other in G2. Through this, cyclin A1 operate the entry and progression in cell cycle. High frequency of cyclin A1 overexpression has been observed in acute myelocytic leukemias, especially those that are at the promyelocyte and myeloblast stages of development.

Cyclin A1 Related Studies

1. Yang R, et al. (1999) Functions of Cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Molecular and Cellular biology. 19 (3): 2400-7.
2. Yang R, et al. (1999) Cyclin A1 expression in leukemia and normal hematopoietic cells. Blood. 93 (6): 2067-74.