All Cyclin A1 reagents are produced in house and quality controlled, including 6 Cyclin A1 Antibody, 15 Cyclin A1 Gene, 1 Cyclin A1 IPKit, 1 Cyclin A1 Lysate, 1 Cyclin A1 Protein, 1 Cyclin A1 qPCR. All Cyclin A1 reagents are ready to use.
Recombinant Cyclin A1 proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-His.
Cyclin A1antibodies are validated with different applications, which are FCM, ICC/IF, IF, ELISA, WB, IP, IHC-P.
Cyclin A1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Cyclin A1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Expression host: Baculovirus-Insect Cells
Cyclin A1 is a member of the highly conserved cyclin family that is characterized by a dramatic periodicity in protein abundance, and belongs to the A-type cyclin subfamily. The mammalian A-type cyclin family consists of two members: cyclin A1 and cyclin A2. Different cyclins exhibit distinct expression. Cyclin A1 is expressed in mice exclusively in the germ cell lineage and high rate of cyclinA1 is found in human testis and certain myeloid leukaemia cells. Cyclin A1 is primarily function in the control of meiosis. It serves as regulator subunits binding to cyclin-dependent kinase 1 (Cdk1) and cyclin-dependent kinase 2 (Cdk2), which give two different kinase activities, one appearing in S phase, the other in G2. Through this, cyclin A1 operate the entry and progression in cell cycle. High frequency of cyclin A1 overexpression has been observed in acute myelocytic leukemias, especially those that are at the promyelocyte and myeloblast stages of development.