Contactin 3 / CNTN3 Protein & Antibody

Contactin 3 / CNTN3 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Contactin 3/CNTN3	Human	Contactin 3/CNTN3/Fc Protein, Recombinant	10174-H02H
Contactin 3/CNTN3	Human	Contactin 3/CNTN3 Protein, Recombinant	10174-H08H
Contactin 3/CNTN3	Mouse	CNTN3 / Contactin-3 Protein, Recombinant	51007-M08H

  10174-H08H: When 5 x 10⁴ cells/well  are added to CNTN3 coated plates (0.8 µg/mL and 100 µL/well), approximately 30%-50% will adhere specifically after 60 minutes at 37℃. Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells.

  10174-H08H: When 5 x 10⁴ cells/well  are added to CNTN3 coated plates (0.8 µg/mL and 100 µL/well), approximately 35%-55% will adhere specifically after 60 minutes at 37℃. Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells.

Contactin 3 / CNTN3 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Contactin 3/CNTN3	WB, ELISA	Mouse Monoclonal Antibody	10174-MM01
Human Contactin 3/CNTN3	WB, ELISA	Contactin 3/CNTN3 Antibody, Rabbit MAb	10174-R006
Human Contactin 3/CNTN3	WB, ELISA	Rabbit Polyclonal Antibody	10174-RP02
Human Contactin 3/CNTN3	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10174-RP03

Contactin 3 / CNTN3 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Contactin 3/CNTN3	Human	CNTN3 cDNA Clone / ORF Clone	HG10174-M
Contactin 3/CNTN3	Mouse	CNTN3 cDNA Clone / ORF Clone	MG51007-G
Contactin 3/CNTN3	Rat	CNTN3 cDNA Clone / ORF Clone	RG80316-G

Contactin 3 / CNTN3 Related Areas

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>Contactin 3/CNTN3

Contactin 3 / CNTN3 Alternative Names

Contactin 3, CNTN3, PANG, BIG-1, KIAA1496, PCS [Homo sapiens]

Contactin 3, Cntn3, Pang [Mus musculus]

Contactin 3 / CNTN3 Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
Contactin 1/CNTN1	Human	Contactin 1/CNTN1 Protein, Recombinant
Contactin 2/CNTN2/TAG1	Human	Contactin 2/CNTN2/TAG-1 Protein, Recombinant
Contactin 5/CNTN5/NB-2	Human	Contactin 5/CNTN5 Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human Contactin 1/CNTN1	WB, ELISA	Mouse Monoclonal Antibody
Human Contactin 2/CNTN2/TAG1	WB, ELISA	Mouse Monoclonal Antibody
Human Contactin 2/CNTN2/TAG1	ELISA	Rabbit Polyclonal Antibody
Human Contactin 2/CNTN2/TAG1	WB, ELISA	Rabbit Polyclonal Antibody(Antigen Affinity Purified)
Human Contactin 5/CNTN5/NB-2	WB, ELISA	Mouse Monoclonal Antibody
Human Contactin 5/CNTN5/NB-2	ELISA	Mouse Monoclonal Antibody
Human Contactin 5/CNTN5/NB-2	WB, ELISA	Contactin 5/CNTN5/NB-2 Antibody, Rabbit MAb
Human Contactin 5/CNTN5/NB-2	WB, ELISA	Rabbit Polyclonal Antibody
Human Contactin 5/CNTN5/NB-2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
Contactin 1/CNTN1	Human	Homo sapiens Contactin 1/CNTN1 transcript variant 1 cDNA Clone(NM_001843.2)
Contactin 2/CNTN2/TAG1	Human	Homo sapiens Contactin 2/CNTN2/TAG-1 cDNA Clone(NM_005076.2)
Contactin 4/CNTN4	Human	Homo sapiens Contactin 4/CNTN4 transcript variant 1 cDNA Clone(NM_175607.1)
Contactin 4/CNTN4	Mouse	Mus musculus Contactin 4/CNTN4 cDNA Clone
Contactin 5/CNTN5/NB-2	Human	Homo sapiens Contactin 5/CNTN5 cDNA Clone(NM_014361.2)

Contactin 3 / CNTN3 Background

Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2(TAG-1), Contactin-3(BIG-1), BIG-2, Contactin-5(NB-2) and NB-3. Since their identification in the late 1980s, Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function of these molecules in axon guidance during development. Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. In contrast, the function of the other four members of this subgroup remained unknown until recently. Contactin-3, also known as CNTN3 ( BIG-1 in rat and PANG in mouse ), is a GPI-linked glycoprotein that is expressed on cerebellar Purkinje cells, amygdaloid and thalamic neurons and olfactory granule cells. In the brain, Contactin-3 is expressed in frontal lobe, occipital lobe, cerebellum and amygdala. Contactin-3 contains 4 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. Human Contactin-3 shares 92% aa identity with mouse Contactin-3.The exact function of Contactin-3 is unclear. Contactin-3 may mediate cell-cell interaction and may promote neurite outgrowth.

Contactin 3 / CNTN3 Related Studies

1. Yoshihara Y, et al. (1994) BIG-1: a new TAG-1/F3-related member of the immunoglobulin superfamily with neurite outgrowth-promoting activity. Neuron 13(2):415-26.
2. Yoshihara Y, et al. (1995) Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily. Journal of neurobiology 28(1):51-69.
3. Yoshihara Y, et al. (1995) Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily. Journal of neurobiology 28(1):51-69.
4. Shimoda Y, et al. (2009) Contactins: Emerging key roles in the development and function of the nervous system. Cell adhesion & migration 3(1):64-70.