Contactin 1 / CNTN1 Protein & Antibody

Contactin 1 / CNTN1 Products

Contactin 1 / CNTN1 Products

Contactin 1 / CNTN1 Protein, Recombinant

Molecule	Species	Description	Cat. No
Contactin 1/CNTN1	Human	Contactin 1/CNTN1 Protein, Recombinant	10383-H08H

  10383-H08H: When cells are added to CNTN1 coated plates (2µg/mL, 100 µL/well), 35%-45% will adhere specifically after 60 minutes at 37℃. Measured by the ability of the immobilized protein to support the adhesion of C6 rat glial cells.

Contactin 1 / CNTN1 Antibody

Molecule	Application	Description	Cat. No
Human Contactin 1/CNTN1	WB, ELISA	Mouse Monoclonal Antibody	10383-MM01
Human Contactin 1/CNTN1	WB, ELISA	Contactin 1 / CNTN1 Antibody	10383-RP02

Contactin 1 / CNTN1 cDNA Clone

Molecule	Species	Description	Cat. No
Contactin 1/CNTN1	Human	Homo sapiens Contactin 1/CNTN1 transcript variant 1 cDNA Clone(NM_001843.2)	HG10383-M
Contactin 1/CNTN1	Mouse	Mouse Contactin 1/CNTN1 cDNA Clone / ORF Clone	MG50933-G
Contactin 1/CNTN1	Rat	CNTN1 cDNA Clone / ORF Clone	RG80315-G

Contactin 1 / CNTN1 Related Areas

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM) >>Contactin 1/CNTN1

Contactin 1 / CNTN1 Alternative Names

Contactin 1, CNTN1, F3, GP135 [Homo sapiens]

Contactin 1, Cntn1, CNTN, AW495098, F3cam [Mus musculus]

Contactin 1 / CNTN1 Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
Contactin 2/CNTN2/TAG1	Human	Contactin 2/CNTN2/TAG-1 Protein, Recombinant
Contactin 3/CNTN3	Human	Contactin 3/CNTN3/Fc Protein, Recombinant
Contactin 3/CNTN3	Human	Contactin 3/CNTN3 Protein, Recombinant
Contactin 5/CNTN5/NB-2	Human	Contactin 5/CNTN5 Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human Contactin 2/CNTN2/TAG1	WB, ELISA	Mouse Monoclonal Antibody
Human Contactin 2/CNTN2/TAG1	ELISA	Rabbit Polyclonal Antibody
Human Contactin 2/CNTN2/TAG1	WB, ELISA	Rabbit Polyclonal Antibody(Antigen Affinity Purified)
Human Contactin 3/CNTN3	WB, ELISA	Mouse Monoclonal Antibody
Human Contactin 3/CNTN3	WB, ELISA	Contactin 3/CNTN3 Antibody, Rabbit MAb
Human Contactin 3/CNTN3	WB, ELISA	Rabbit Polyclonal Antibody
Human Contactin 3/CNTN3	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human Contactin 5/CNTN5/NB-2	WB, ELISA	Mouse Monoclonal Antibody
Human Contactin 5/CNTN5/NB-2	ELISA	Mouse Monoclonal Antibody
Human Contactin 5/CNTN5/NB-2	WB, ELISA	Contactin 5/CNTN5/NB-2 Antibody, Rabbit MAb
Human Contactin 5/CNTN5/NB-2	WB, ELISA	Rabbit Polyclonal Antibody
Human Contactin 5/CNTN5/NB-2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
Contactin 2/CNTN2/TAG1	Human	Homo sapiens Contactin 2/CNTN2/TAG-1 cDNA Clone(NM_005076.2)
Contactin 3/CNTN3	Human	Homo sapiens Contactin 3/CNTN3 cDNA Clone(NM_020872.1)
Contactin 4/CNTN4	Human	Homo sapiens Contactin 4/CNTN4 transcript variant 1 cDNA Clone(NM_175607.1)
Contactin 4/CNTN4	Mouse	Mus musculus Contactin 4/CNTN4 cDNA Clone
Contactin 5/CNTN5/NB-2	Human	Homo sapiens Contactin 5/CNTN5 cDNA Clone(NM_014361.2)

Contactin 1 / CNTN1 Background

Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3 (BIG-1), BIG-2, Contactin-5 (NB-2) and NB-3. Since their identification in the late 1980s, Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function of these molecules in axon guidance during development. Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. In contrast, the function of the other four members of this subgroup remained unknown until recently. Contactin-1 is a cell surface adhesion molecule that is normally expressed by neurons and oligodendrocytes. Particularly high levels of Contactin-1 are present during brain development. Contactin-1 and Contactin-2 are differentially expressed in a number of neuronal tissues during development, and they interact with several ligands including Nr-CAM, L1, NCAM, neurocan, phosphacan, and tenascin. As a cell adhesion molecule, Contactin-1 plays a role in the formation of axon connections in the developing nervous system. It was demonstrated that Contactin-1 participates in signal pathways via its association with Contactin-associated protein (CNTNAP1), receptor protein tyrosine phosphatase beta (RPTPb) and NOTCH1. Contactin-1 is also involved in paranodal axo-glial junction formation and oligodendrocytes generation. Furthermore, studies indicated that Contactin-1 functions importantly in the invasion and metastasis of lung adenocarcinoma cells. Contactin-1 may also significantly influence the functional expression and distribution of Na+ channels in neurons.

Contactin 1 / CNTN1 Related Studies

1. Kazarinova NK, et al. (2001) Contactin associates with Na+ channels and increases their functional expression. J Neurosci. 21 (19):7517-25.
2. Eckerich C, et al. (2006) Contactin is expressed in human astrocytic gliomas and mediates repulsive effects. Glia. 53(1):1-12.
3. Su JL, et al. (2006) Knockdown of contactin-1 expression suppresses invasion and metastasis of lung adenocarcinoma. Cancer research 66 (5):2553-61.
4. Compton AG, et al. (2008) Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy. Am J Hum Genet. 83 (6):714-24.
5. Mikami T, et al. (2009) Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E. J Biol Chem. 284(7):4494-9.