Complexin-2 / CPLX2 Protein

Complexin-2 / CPLX2 Products

Complexin-2 / CPLX2 Protein, Recombinant

Molecule	Species	Description	Cat. No
Complexin-2/CPLX2	Human	Complexin-2/CPLX2 Protein, Recombinant	11927-H07E

Complexin-2 / CPLX2 Antibody

Molecule	Application	Description	Cat. No
Human Complexin-2/CPLX	WB,Elisa	Rabbit Polyclonal Antibody	11927-RP01
Human Complexin-2/CPLX	WB,Elisa	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11927-RP02

Complexin-2 / CPLX2 Related Areas

Neuroscience>>Synaptic Vesicle>>Complexin-2/CPLX2

Complexin-2 / CPLX2 Alternative Names

Complexin-2, CPLX2, 921-L, CPX-2, CPX2, Hfb1, MGC138492, CPX II, complexin II, complexin-2, synaphin-1 [Homo sapiens]

Complexin-2, Cplx2, 921-L, AI413745, AW492120, CPX II, complexin II, complexin-2, synaphin-1 [Mus musculus]

Complexin-2 / CPLX2 Background

Complexin-2 (CPLX2), a member of the complexin/synaphin family, is a soluble pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals. Complexins are soluble proteins that regulate the activity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes necessary for vesicle fusion. Complexins are unable to bind to monomeric SNARE proteins but bind with high affinity to ternary SNARE complexes and with lower affinity to target SNARE complexes. Complexin 1 (CX1) and complexin 2 (CX2) are presynaptic proteins that modulate neurotransmitter release and are used as markers of inhibitory and excitatory synapses, respectively. CPLX2 is localized in pre-synaptic terminals in mature brain. The G71-P89 region of CPLX2 is essential and sufficient for preferential axonal distribution. CPLX2 participates in the Ca(2+)-sensitive regulatory pathway for zymogen granule exocytosis. Complexin-2 is a key player in normal neurological function, and its downregulation could lead to changes in neurotransmitter release sufficient to cause significant behavioural abnormalities such as depression. It is involved in synaptogenesis and the modulation of neurotransmitter release.

Complexin-2 / CPLX2 Related Studies

1. Lee HJ, et al. (2005) Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. Behav Brain Funct. 1: 15.
2. Salimi K, et al. (2008) Regulation of complexin 1 and complexin 2 in the developing human prefrontal cortex. Synapse. 62(4): 273-82.
3. Kataoka M, et al. (2009) Identification of a minimal segment of complexin II essential for preferential distribution in axons. J Neurochem. 108(5): 1109-15.
4. Glynn D, et al. (2010) Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse. Hum Mol Genet. 19(17): 3402-12.
5. Falkowski MA, et al. (2010) Complexin 2 modulates vesicle-associated membrane protein (VAMP) 2-regulated zymogen granule exocytosis in pancreatic acini. J Biol Chem. 285(46): 35558-66.