Anti-CPLX2 Antibody

Cat: 11927-RP02

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Anti-CPLX2 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-CPLX2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CPLX2
Immunogen
Recombinant Human Complexin-2 / CPLX2 protein (Catalog#11927-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human Complexin-2 / CPLX2 (rh Complexin-2 / CPLX2; Catalog#11927-H07E; Q6PUV4-1; Asp 2-Lys 134). Complexin-2 / CPLX2 specific IgG was purified by Human Complexin-2 / CPLX2 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Anti-CPLX2 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CPLX2 Antibody Alternative Names

Anti-921-L Antibody;Anti-CPX-2 Antibody;Anti-CPX2 Antibody;Anti-Hfb1 Antibody

CPLX2 Background Information

Complexin-2 (CPLX2), a member of the complexin/synaphin family, is a soluble pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals. Complexins are soluble proteins that regulate the activity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes necessary for vesicle fusion. Complexins are unable to bind to monomeric SNARE proteins but bind with high affinity to ternary SNARE complexes and with lower affinity to target SNARE complexes. Complexin 1 (CX1) and complexin 2 (CX2) are presynaptic proteins that modulate neurotransmitter release and are used as markers of inhibitory and excitatory synapses, respectively. CPLX2 is localized in pre-synaptic terminals in mature brain. The G71-P89 region of CPLX2 is essential and sufficient for preferential axonal distribution. CPLX2 participates in the Ca(2+)-sensitive regulatory pathway for zymogen granule exocytosis. Complexin-2 is a key player in normal neurological function, and its downregulation could lead to changes in neurotransmitter release sufficient to cause significant behavioural abnormalities such as depression. It is involved in synaptogenesis and the modulation of neurotransmitter release.

Full Name
complexin 2
References
  • Lee HJ, et al. (2005) Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. Behav Brain Funct. 1: 15.
  • Salimi K, et al. (2008) Regulation of complexin 1 and complexin 2 in the developing human prefrontal cortex. Synapse. 62(4): 273-82.
  • Kataoka M, et al. (2009) Identification of a minimal segment of complexin II essential for preferential distribution in axons. J Neurochem. 108(5): 1109-15.
  • Glynn D, et al. (2010) Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse. Hum Mol Genet. 19(17): 3402-12.
  • Falkowski MA, et al. (2010) Complexin 2 modulates vesicle-associated membrane protein (VAMP) 2-regulated zymogen granule exocytosis in pancreatic acini. J Biol Chem. 285(46): 35558-66.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CPLX2 Antibody Rabbit Monoclonal FCM,ICC/IF,IF 11927-R021
    Anti-CPLX2 Antibody Rabbit Polyclonal ELISA 11927-RP01
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