Complement Factor H Protein & Antibody

Complement Factor H Products

Complement Factor H Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
Complement Factor H/CFH	Human	Complement Factor H/CFH Protein, Recombinant	10714-H08H

  10714-H08H:  Measured by its ability to bind biotinylated human DMP1 in a functional Elisa.

Complement Factor H Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat No
Human Complement Factor H/CFH	WB, ELISA	Complement Factor H/CFH Antibody, Rabbit PAb	10714-RP01
Human Complement Factor H/CFH	WB, ELISA	Complement Factor H/CFH Antibody, Rabbit PAb (Antigen Affinity Purified)	10714-RP02

Complement Factor H cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
Complement Factor H/CFH	Human	Homo sapiens Complement Factor H/CFH cDNA Clone	HG10714-M

Complement Factor H Related Areas

Immunology>>Innate Immunity>>Complement System>>Complement Factor H/CFH

Complement Factor H Alternative Names

Complement Factor H, CFH, RP1-177P10.1, AHUS1, ARMD4, ARMS1, CFHL3, FH, FHL1, HF, HF1, HF2, HUS, MGC88246 [Homo sapiens]

Complement Factor H, Cfh, Mud-1, NOM, Sas-1, Sas1 [Mus musculus]

Complement Factor H Related Products

Protein Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
C1qB	Human	C1qB Protein, Recombinant
C1QBP/HABP1	Human	C1QBP/HABP1 Protein, Recombinant
C1QBP/HABP1	Mouse	C1QBP/HABP1 Protein, Recombinant
Complement C1s	Human	Complement C1s Protein, Recombinant
Complement C2	Human	Complement C2/Fc Protein, Recombinant
Complement C2	Human	Complement C2 Protein, Recombinant
Complement C5a	Human	Complement C5a Protein, Recombinant
CD55/DAF	Human	CD55/DAF/Fc Protein, Recombinant
CD55/DAF	Human	CD55/DAF Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human CD55/DAF	WB, ELISA	Mouse Monoclonal Antibody
Human CD55/DAF	WB, ELISA	CD55/DAF Antibody, Rabbit MAb
Human CD55/DAF	WB, ELISA	Rabbit Polyclonal Antibody
Human Complement C2	WB, ELISA	Complement C2 Antibody, Rabbit MAb
Human Complement C5a	WB, ELISA	Complement C5a Antibody, Rabbit PAb
Human Complement C5a	WB, ELISA	Complement C5a Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
C1qB	Human	Homo sapiens C1qB cDNA Clone(NM_000491.3)
C1qB	Mouse	Mus musculus C1qB cDNA Clone
Complement C1r	Human	Homo sapiens Complement C1r cDNA Clone(NM_001733.4)
Complement C1s	Human	Homo sapiens Complement C1s transcript variant 1 cDNA Clone(NM_001734.2)
Complement C2	Human	Homo sapiens Complement C2 cDNA Clone(NM_000063.3)
adipsin/Complement Factor D	Human	Homo sapiens adipsin/Complement Factor D cDNA Clone(NM_001928.2)
CD55/DAF	Human	Homo sapiens CD55/DAF transcript variant 1 cDNA Clone(NM_000574.3)

Complement Factor H Background

Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death. Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. CFH protects self cells from complement activation but not bacteria/viruses. Due to the central role that CFH plays in the regulation of complement, there are many clinical implications arrising from aberrant CFH activity. Mutations in the Factor H gene are associated with severe and diverse diseases including the rare renal disorders hemolytic uremic syndrome (HUS) and membranoproliferative glomerulonephritis (MPGN) also termed dense deposit disease (DDD), membranoproliferative glomuleronephritis type II or dense deposit disease, as well as the more frequent retinal disease age related macular degeneration (AMD). In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3) interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin.

Complement Factor H Related Studies

1. Zipfel PF. (2001) Complement factor H: physiology and pathophysiology. Semin Thromb Hemost. 27(3): 191-9.
2. Zipfel PF, et al. (2008) The complement fitness factor H: role in human diseases and for immune escape of pathogens, like pneumococci. Vaccine. 26 Suppl 8: I67-74.
3. Ferreira VP, et al. (2010) Complement control protein factor H: the good, the bad, and the inadequate. Mol Immunol. 47(13): 2187-97.
4. Donoso LA, et al. (2010) The role of complement Factor H in age-related macular degeneration: a review. Surv Ophthalmol. 55(3): 227-46.