Anti-Factor H Antibody

Cat: 10714-RP01
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All Factor H Reagents
Anti-Factor H Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Factor H Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Factor H
Immunogen
Recombinant Human CFH protein (Catalog#10714-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CFH (rh CFH; Catalog#10714-H08H; NP_000177.2; Ser 860-Arg 1231). Total IgG was purified by Protein A affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Factor H Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Factor H Antibody Alternative Names
Anti-AHUS1 Antibody;Anti-AMBP1 Antibody;Anti-ARMD4 Antibody;Anti-ARMS1 Antibody;Anti-CFHL3 Antibody;Anti-FH Antibody;Anti-FHL1 Antibody;Anti-HF Antibody;Anti-HF1 Antibody;Anti-HF2 Antibody;Anti-HUS Antibody
Factor H Background Information

Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death. Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. CFH protects self cells from complement activation but not bacteria/viruses. Due to the central role that CFH plays in the regulation of complement, there are many clinical implications arrising from aberrant CFH activity. Mutations in the Factor H gene are associated with severe and diverse diseases including the rare renal disorders hemolytic uremic syndrome (HUS) and membranoproliferative glomerulonephritis (MPGN) also termed dense deposit disease (DDD), membranoproliferative glomuleronephritis type II or dense deposit disease, as well as the more frequent retinal disease age related macular degeneration (AMD). In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3) interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin.

Full Name
complement factor H
References
  • Zipfel PF. (2001) Complement factor H: physiology and pathophysiology. Semin Thromb Hemost. 27(3): 191-9.
  • Zipfel PF, et al. (2008) The complement fitness factor H: role in human diseases and for immune escape of pathogens, like pneumococci. Vaccine. 26 Suppl 8: I67-74.
  • Ferreira VP, et al. (2010) Complement control protein factor H: the good, the bad, and the inadequate. Mol Immunol. 47(13): 2187-97.
  • Donoso LA, et al. (2010) The role of complement Factor H in age-related macular degeneration: a review. Surv Ophthalmol. 55(3): 227-46.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Factor H Antibody Rabbit Polyclonal ELISA 51160-RP01
    Anti-Factor H Antibody Rabbit Monoclonal IHC-P 51160-R012
    Anti-Factor H Antibody Rabbit Polyclonal ELISA 51160-T16
    Anti-Factor H Antibody Mouse Monoclonal ELISA 10714-MM05
    Anti-Factor H Antibody Rabbit Polyclonal ELISA 10714-RP02
    Anti-Factor H Antibody Mouse Monoclonal ELISA(Cap) 10714-MM02
    Anti-Factor H Antibody Rabbit Polyclonal ELISA 10714-T16
    Anti-Factor H Antibody Mouse Monoclonal ELISA(Det) 10714-MM03
    Anti-Factor H Antibody Rabbit Monoclonal ELISA 10714-R305
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