C5a (Protein|Antibody|cDNA Clone|ELISA Kit)

All C5a reagents are produced in house and quality controlled, including 7 C5a Antibody, 2 C5a ELISA, 27 C5a Gene, 1 C5a Lysate, 3 C5a Protein, 1 C5a qPCR. All C5a reagents are ready to use.

Recombinant C5a proteins are expressed by E. coli, HEK293 Cells with fusion tags as Native, N-Flag & C-His.

C5aantibodies are validated with different applications, which are ELISA, IHC-P, ELISA(Cap).

C5acDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each C5a of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

C5aELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.

C5a Protein (3)

Species

C5a Protein, Mouse, Recombinant

51136-MNAE

Expression host: E. coli

Mouse C5a/Complement 5a  Protein 15327

C5a Protein, Human, Recombinant

10604-HNAE

Expression host: E. coli

Human C5a/Complement 5a  Protein 8961

C5a Protein, Human, Recombinant (His & FLAG Tag)

13416-H18H

Expression host: HEK293 Cells

Human C5a/Complement 5a  Protein 18604
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C5a Antibody (7)

Application Clonality
Host

Anti-C5a Antibody

10604-MM04

Application: ELISA

Clonality: MAb

Anti-C5a Antibody

10604-MM06

Application: ELISA(Cap)

Clonality: MAb

Anti-C5a Antibody

10604-R215

Application: IHC-P

Clonality: MAb

Human C5a/Complement 5a  Immunohistochemistry(IHC) 4637

Anti-C5a Antibody

10604-R241

Application: ELISA

Clonality: MAb

Anti-C5a Antibody

10604-RP02

Application: ELISA

Clonality: PAb

Anti-C5a Antibody

10604-T16

Application: ELISA

Clonality: PAb

Anti-C5a Antibody

10604-R442

Application: ELISA

Clonality: MAb

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C5a ELISA KIT & match antibody elias pair set ( 2 )

C5a Matched ELISA Antibody Pair Set,Human

SEK10604

Assay Range: 31.25 pg/ml

Human C5a/Complement 5a  ELISA Pair Set Standard Curve 7102

C5a Matched ELISA Antibody Pair Set,Human

SEKA10604

Assay Range: 15.63 pg/ml

Human C5a/Complement 5a  ELISA Pair Set Standard Curve 7102

C5a cDNA Clone (27)

Mouse
Human
Rat

C5a qPCR Primer (1)

C5a Lysate (1)

C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity form, C5a des-Arg. C5a is an extremely potent proinflammatory mediator, as well as a potent chemotactic factor for neutrophils and other leukocytes. It causes histamine release, increases in vascular permeability, induces several cytokines production from leukocytes, enhances neutrophil-endothelial cell adhesion, and augments the humoral and cell-mediated immune response. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg. Acting via a classical G protein-coupled receptor, CD88, C5a and C5adesArg exert a number of effects essential to the innate immune response, while their actions at the more recently discovered non-G protein-coupled receptor, C5L2 (or GPR77), remain unclear. The widespread expression of C5a receptors throughout the body allows C5a to elicit a broad range of effects. Thus, C5a has been found to be a significant pathogenic driver in a number of immuno-inflammatory diseases, making C5a inhibition an attractive therapeutic strategy. C5a is a strong chemoattractant and is involved in the recruitment of inflammatory cells such as neutrophils, eosinophils, monocytes, and T lymphocytes, in activation of phagocytic cells and release of granule-based enzymes and generation of oxidants, all of which may contribute to innate immune functions or tissue damage. Accordingly, the anaphylatoxin C5a is implicated in a variety of diseases such as rheumatoid arthritis, systemic lupus erythematosus, reperfusion injury, Alzheimer's disease, and sepsis.

Protein
Antibody
ELISA
Gene
qPCR
Lysate
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