Complement C5a Protein & Antibody

Complement Component 5a

Complement C5a Products

Complement C5a Protein, Recombinant

Molecule	Species	Description	Cat. No
Complement C5a	Human	Complement C5a Protein, Recombinant	10604-HNAE

  10604-HNAE: ED₅₀ = 7.2 ng / ml. Measured by its ability to induce N-acetyl-ß-D-glucosaminidase release from differentiated U937 human histiocytic lymphoma cells.

Complement C5a Antibody

Molecule	Application	Description	Cat. No
Human Complement C5a	WB, ELISA	Complement C5a Antibody, Rabbit PAb	10604-RP01
Human Complement C5a	WB, ELISA	Complement C5a Antibody, Rabbit PAb (Antigen Affinity Purified)	10604-RP02

Complement C5a Related Areas

Immunology>>Innate Immunity>>Complement System>>Complement C5a

Complement C5a Alternative Names

C5a , CPAMD4, FLJ17816, FLJ17822, MGC142298

Complement C5a Related Products

Recombinant Protein Products

Molecule	Application	Description
C1qB	Human	C1qB Protein, Recombinant
C1QBP/HABP1	Human	C1QBP/HABP1 Protein, Recombinant
C1QBP/HABP1	Mouse	C1QBP/HABP1 Protein, Recombinant
Complement C1s	Human	Complement C1s Protein, Recombinant
Complement C2	Human	Complement C2/Fc Protein, Recombinant
Complement C2	Human	Complement C2 Protein, Recombinant
Complement Factor H/CFH	Human	Complement Factor H/CFH Protein, Recombinant
CD55/DAF	Human	CD55/DAF/Fc Protein, Recombinant
CD55/DAF	Human	CD55/DAF Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human CD55/DAF	WB, ELISA	Mouse Monoclonal Antibody
Human CD55/DAF	WB, ELISA	CD55/DAF Antibody, Rabbit MAb
Human CD55/DAF	WB, ELISA	Rabbit Polyclonal Antibody
Human Complement C2	WB, ELISA	Complement C2 Antibody, Rabbit MAb
Human Complement Factor H/CFH	WB, ELISA	Complement Factor H/CFH Antibody, Rabbit PAb
Human Complement Factor H/CFH	WB, ELISA	Complement Factor H/CFH Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
Complement C1s	Human	Homo sapiens Complement C1s transcript variant 1 cDNA Clone(NM_001734.2)
Complement C1r	Human	Homo sapiens Complement C1r cDNA Clone(NM_001733.4)
C1qB	Human	Homo sapiens C1qB cDNA Clone(NM_000491.3)
C1qB	Mouse	Mus musculus C1qB cDNA Clone
Complement C2	Human	Homo sapiens Complement C2 cDNA Clone(NM_000063.3)
adipsin/Complement Factor D	Human	Homo sapiens adipsin/Complement Factor D cDNA Clone(NM_001928.2)
Complement Factor H/CFH	Human	Homo sapiens Complement Factor H/CFH cDNA Clone
CD55/DAF	Human	Homo sapiens CD55/DAF transcript variant 1 cDNA Clone(NM_000574.3)

Complement C5a Background

C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity form, C5a des-Arg. C5a is an extremely potent proinflammatory mediator, as well as a potent chemotactic factor for neutrophils and other leukocytes. It causes histamine release, increases in vascular permeability, induces several cytokines production from leukocytes, enhances neutrophil-endothelial cell adhesion, and augments the humoral and cell-mediated immune response. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg. Acting via a classical G protein-coupled receptor, CD88, C5a and C5adesArg exert a number of effects essential to the innate immune response, while their actions at the more recently discovered non-G protein-coupled receptor, C5L2 (or GPR77), remain unclear. The widespread expression of C5a receptors throughout the body allows C5a to elicit a broad range of effects. Thus, C5a has been found to be a significant pathogenic driver in a number of immuno-inflammatory diseases, making C5a inhibition an attractive therapeutic strategy. C5a is a strong chemoattractant and is involved in the recruitment of inflammatory cells such as neutrophils, eosinophils, monocytes, and T lymphocytes, in activation of phagocytic cells and release of granule-based enzymes and generation of oxidants, all of which may contribute to innate immune functions or tissue damage. Accordingly, the anaphylatoxin C5a is implicated in a variety of diseases such as rheumatoid arthritis, systemic lupus erythematosus, reperfusion injury, Alzheimer's disease, and sepsis.

Complement C5a Related Studies

1. Guo RF, et al.. (2005) Role of C5a in inflammatory responses. Annu Rev Immunol. 23: 821-52.
2. Guo RF, et al. (2006) C5a, a therapeutic target in sepsis. Recent Pat Antiinfect Drug Discov. 1(1): 57-65.
3. Manthey HD, et al. (2009) Complement component 5a (C5a). Int J Biochem Cell Biol. 41(11): 2114-7.