Anti-C5a Antibody

Cat: 10604-RP01

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All C5a Reagents
Anti-C5a Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-C5a Antibody
Validated applications
Species reactivity
Reacts with: Human
Human C5a
Recombinant Human C5a protein (Catalog#10604-HNAE)
Produced in rabbits immunized with purified, recombinant Human C5a (rh C5a; Catalog#10604-HNAE; Leu 679-Arg 751). Total IgG was purified by Protein A affinity chromatography .
Polyclonal Rabbit IgG
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-C5a Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-C5a Antibody Alternative Names
Anti-C5a Antibody;Anti-C5b Antibody;Anti-C5D Antibody;Anti-C5Da Antibody;Anti-Complement 5a Antibody;Anti-CPAMD4 Antibody;Anti-ECLZB Antibody
C5a Background Information

C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity form, C5a des-Arg. C5a is an extremely potent proinflammatory mediator, as well as a potent chemotactic factor for neutrophils and other leukocytes. It causes histamine release, increases in vascular permeability, induces several cytokines production from leukocytes, enhances neutrophil-endothelial cell adhesion, and augments the humoral and cell-mediated immune response. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg. Acting via a classical G protein-coupled receptor, CD88, C5a and C5adesArg exert a number of effects essential to the innate immune response, while their actions at the more recently discovered non-G protein-coupled receptor, C5L2 (or GPR77), remain unclear. The widespread expression of C5a receptors throughout the body allows C5a to elicit a broad range of effects. Thus, C5a has been found to be a significant pathogenic driver in a number of immuno-inflammatory diseases, making C5a inhibition an attractive therapeutic strategy. C5a is a strong chemoattractant and is involved in the recruitment of inflammatory cells such as neutrophils, eosinophils, monocytes, and T lymphocytes, in activation of phagocytic cells and release of granule-based enzymes and generation of oxidants, all of which may contribute to innate immune functions or tissue damage. Accordingly, the anaphylatoxin C5a is implicated in a variety of diseases such as rheumatoid arthritis, systemic lupus erythematosus, reperfusion injury, Alzheimer's disease, and sepsis.

Full Name
complement component 5
  • Guo RF, et al.. (2005) Role of C5a in inflammatory responses. Annu Rev Immunol. 23: 821-52.
  • Guo RF, et al. (2006) C5a, a therapeutic target in sepsis. Recent Pat Antiinfect Drug Discov. 1(1): 57-65.
  • Manthey HD, et al. (2009) Complement component 5a (C5a). Int J Biochem Cell Biol. 41(11): 2114-7.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-C5a Antibody Rabbit Polyclonal ELISA 10604-T16
    Anti-C5a Antibody Mouse Monoclonal ELISA 10604-MM04
    Anti-C5a Antibody Mouse Monoclonal ELISA(Cap) 10604-MM06
    Anti-C5a Antibody Rabbit Monoclonal IHC-P 10604-R215
    Anti-C5a Antibody Rabbit Monoclonal ELISA 10604-R241
    Anti-C5a Antibody Rabbit Polyclonal ELISA 10604-RP02
    Anti-C5a Antibody Rabbit Monoclonal ELISA 10604-R442
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