Complement C2 Protein & Antibody

Complement Component 2

Complement C2 Products

Complement C2 Protein, Recombinant

Molecule	Species	Description	Cat. No
Complement C2	Human	Complement C2/Fc Protein, Recombinant	10154-H02H
Complement C2	Human	Complement C2 Protein, Recombinant	10154-H08H

Complement C2 Antibody

Molecule	Application	Description	Cat. No
Human Complement C2	WB, ELISA	Complement C2 Antibody, Rabbit MAb	10154-R002

Complement C2 cDNA Clone

Molecule	Species	Description	Cat. No
Complement C2	Human	Homo sapiens Complement C2 cDNA Clone(NM_000063.3)	HG10154-M

Complement C2 Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Complement System>>Complement C2

Immunology>>Innate Immunity>>Complement System>>Complement C2

Complement C2 Alternative Names

C2 , DADB-122G4.1, CO2, DKFZp779M0311 [Homo sapiens]

C2 , RP24-317H19.3 [Mus musculus]

Complement C2 Related Products

Recombinant Protein Products

Molecule	Application	Description
C1qB	Human	C1qB Protein, Recombinant
C1QBP/HABP1	Human	C1QBP/HABP1 Protein, Recombinant
C1QBP/HABP1	Mouse	C1QBP/HABP1 Protein, Recombinant
Complement C1s	Human	Complement C1s Protein, Recombinant
Complement C5a	Human	Complement C5a Protein, Recombinant
Complement Factor H/CFH	Human	Complement Factor H/CFH Protein, Recombinant
CD55/DAF	Human	CD55/DAF/Fc Protein, Recombinant
CD55/DAF	Human	CD55/DAF Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human CD55/DAF	WB, ELISA	Mouse Monoclonal Antibody
Human CD55/DAF	WB, ELISA	CD55/DAF Antibody, Rabbit MAb
Human CD55/DAF	WB, ELISA	Rabbit Polyclonal Antibody
Human Complement C5a	WB, ELISA	Complement C5a Antibody, Rabbit PAb
Human Complement C5a	WB, ELISA	Complement C5a Antibody, Rabbit PAb (Antigen Affinity Purified)
Human Complement Factor H/CFH	WB, ELISA	Complement Factor H/CFH Antibody, Rabbit PAb
Human Complement Factor H/CFH	WB, ELISA	Complement Factor H/CFH Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
Complement C1s	Human	Homo sapiens Complement C1s transcript variant 1 cDNA Clone(NM_001734.2)
Complement C1r	Human	Homo sapiens Complement C1r cDNA Clone(NM_001733.4)
C1qB	Human	Homo sapiens C1qB cDNA Clone(NM_000491.3)
C1qB	Mouse	Mus musculus C1qB cDNA Clone
adipsin/Complement Factor D	Human	Homo sapiens adipsin/Complement Factor D cDNA Clone(NM_001928.2)
Complement Factor H/CFH	Human	Homo sapiens Complement Factor H/CFH cDNA Clone
CD55/DAF	Human	Homo sapiens CD55/DAF transcript variant 1 cDNA Clone(NM_000574.3)

 

Complement C2 Background

Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in extrahepatic tissues. This pathway is triggered by a multimolecular complex C1, and subsequently the single-chain form of C2 is cleaved into two chains referred to C2a and C2b by activated C1. The second component of complement (C2) is a multi-domain serine protease that provides catalytic activity for the C3 and C5 convertases of the classical and lectin pathways of human complement. C4b and C2 was investigated by surface plasmon resonance. C2a containing a serine protease domain combines with complement component C4b to form the C3 convertase C4b2a which is responsible for C3 activation, and leads to the stimulation of adaptive immune responses via Lectin pathway. C2 bound to C4b is cleaved by classical (C1s) or lectin (MASP2) proteases to produce C4bC2a. C2 has the same serine protease domain as C4bC2a but in an inactive zymogen-like conformation, requiring cofactor-induced conformational change for activity. Deficiency of C2 (C2D) is the most common genetic deficiency of the complement system, and two types of C2D have been recognized in the context of specific MHC haplotypes. C2D in human is reported to increase susceptibility to infection, and is associated with certain autoimmune diseases, such as rheumatological disorders.

Complement C2 Related Studies

1. Laich A, et al. (2002) Complement C4bC2 complex formation: an investigation by surface plasmon resonance. Biochim Biophys Acta. 1544(1-2): 96-112.
2. Halili MA, et al. (2009) Complement component C2, inhibiting a latent serine protease in the classical pathway of complement activation. Biochemistry. 48(35): 8466-72.
3. Krishnan V, et al. (2009) The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation. Acta Crystallogr D Biol Crystallogr. 65(Pt 3): 266-74.