Complement C1s Protein

Complement Component 1, s subcomponent

Complement C1s Products

Complement C1s Protein, Recombinant

Molecule	Species	Description	Cat. No
Complement C1s	Human	Complement C1s Protein, Recombinant	10220-H08H

Complement C1s Antibody

Molecule	Application	Description	Cat. No
Complement C1s	Human	Complement C1s Antibody, Mouse MAb	10220-MM06

Complement C1s ELISA Kit

Molecule	Application	Description	Cat. No
Human Complement C1s	ELISA	Complement C1s ELISA Kit	SEK10220

Complement C1s cDNA Clone

Molecule	Species	Description	Cat. No
Complement C1s	Human	Homo sapiens Complement C1s transcript variant 1 cDNA Clone(NM_001734.2)	HG10220-M
Complement C1s	Mouse	Mouse Complement C1s cDNA Clone / ORF Clone	MG50979-G

Complement C1s Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Complement System>>Complement C1s

Immunology>>Innate Immunity>>Complement System>>Complement C1s

Complement C1s Alternative Names

C1S, FLJ44757

Complement C1s Related Products

Recombinant Protein Products

Molecule	Application	Description
C1qB	Human	C1qB Protein, Recombinant
C1QBP/HABP1	Human	C1QBP/HABP1 Protein, Recombinant
C1QBP/HABP1	Mouse	C1QBP/HABP1 Protein, Recombinant
Complement C2	Human	Complement C2/Fc Protein, Recombinant
Complement C2	Human	Complement C2 Protein, Recombinant
Complement C5a	Human	Complement C5a Protein, Recombinant
Complement Factor H/CFH	Human	Complement Factor H/CFH Protein, Recombinant
CD55/DAF	Human	CD55/DAF/Fc Protein, Recombinant
CD55/DAF	Human	CD55/DAF Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human CD55/DAF	WB, ELISA	Mouse Monoclonal Antibody
Human CD55/DAF	WB, ELISA	CD55/DAF Antibody, Rabbit MAb
Human CD55/DAF	WB, ELISA	Rabbit Polyclonal Antibody
Human Complement C2	WB, ELISA	Complement C2 Antibody, Rabbit MAb
Human Complement C5a	WB, ELISA	Complement C5a Antibody, Rabbit PAb
Human Complement C5a	WB, ELISA	Complement C5a Antibody, Rabbit PAb (Antigen Affinity Purified)
Human Complement Factor H/CFH	WB, ELISA	Complement Factor H/CFH Antibody, Rabbit PAb
Human Complement Factor H/CFH	WB, ELISA	Complement Factor H/CFH Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
Complement C1r	Human	Homo sapiens Complement C1r cDNA Clone(NM_001733.4)
C1qB	Human	Homo sapiens C1qB cDNA Clone(NM_000491.3)
C1qB	Mouse	Mus musculus C1qB cDNA Clone
Complement C2	Human	Homo sapiens Complement C2 cDNA Clone(NM_000063.3)
adipsin/Complement Factor D	Human	Homo sapiens adipsin/Complement Factor D cDNA Clone(NM_001928.2)
Complement Factor H/CFH	Human	Homo sapiens Complement Factor H/CFH cDNA Clone
CD55/DAF	Human	Homo sapiens CD55/DAF transcript variant 1 cDNA Clone(NM_000574.3)

Complement C1s Background

Complement is an integral component of the adaptive and innate immune systems and represents one of the major effector systems for the immune responses. The classical complement pathway is triggered by C1, a complex composed of the binding protein C1q and two proenzymes, C1r and C1s. Upon binding of IgG to the head of C1q, C1r undergoes autoactivation and in turn cleaves and activates C1s. C1r and C1s, the proteases responsible for activation and proteolytic activity of the C1 complex of complement, share similar overall structural organizations featuring five nonenzymic protein modules (two CUB modules surrounding a single EGF module, and a pair of CCP modules) followed by a serine protease domain. Besides highly specific proteolytic activities, both proteases exhibit interaction properties associated with their N-terminal regions. In contrast, C1r and C1s widely differ from each other by their glycosylation patterns: both proteins contain Asn-linked carbohydrates, but four glycosylation sites are present on C1r, and only two on C1s. As a highly specific serine protease, C1s executes the catalytic function of the C1 complex: the cleavage of C4 and C2, and thus instigates a sequence of activation steps of other components of the complement system, culminating in the formation of the membrane attack complex which induces cell lysis. Like other complement serine proteases C1s has restricted substrate specificity and it is engaged into specific interactions with other subcomponents of the complement system. The only other protein known to interact with C1s physiologically is SerpinC1, an inhibitor of serine protease, which inhibits C1s activity and thus plays a regulatory role in controlling the function of C1s enzyme.

Complement C1s Related Studies

1. Arlaud GJ, et al. (1989) Structure and function of C1r and C1s: current concepts. Behring Inst Mitt. (84): 56-64.
2. Thielens NM, et al. (1999) Structure and functions of the interaction domains of C1r and C1s: keystones of the architecture of the C1 complex. Immunopharmacology. 42(1-3): 3-13.
3. Gál P, et al. (2002) C1s, the protease messenger of C1. Structure, function and physiological significance. Immunobiology. 205(4-5): 383-94.