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Colony-Stimulating Factor (CSF) & Receptor

Colony-stimulating factors (CSFs) are secreted glycoproteins which regulate bone marrow production of circulating red and white cells, and platelets. Colony-stimulating factors bind to receptors on the surfaces of hemopoietic stem cells and thereby activate intracellular signaling pathways which induce the cells to proliferate and differentiate into a specific kind of blood cell. Colony-stimulating factors include: macrophage colony-stimulating factor (M-CSF), Granulocyte macrophage colony-stimulating factor (GM-CSF) and Granulocyte colony-stimulating factor (G-CSF).

Sino Biological offers a comprehensive set of tools for research on colony-stimulating factors (CSFs) and their receptors, including recombinant proteins, antibodies (rabbit mAbs, mouse mAbs, rabbit pAbs), ELISA kits, and ORF cDNA clones.

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    Colony-Stimulating Factor (CSF) & Receptor Background

    Colony-stimulating factors (CSFs), also called haematopoietic growth factors, are secreted glycoproteins which regulate bone marrow production of circulating red and white cells, and platelets. Colony-stimulating factors bind to receptor proteins on the surfaces of hemopoietic stem cells and thereby activate intracellular signaling pathways which can cause the cells to proliferate and differentiate into a specific kind of blood cell. Colony-stimulating factors include: macrophage colony-stimulating factor (M-CSF), Granulocyte macrophage colony-stimulating factor (GM-CSF) and Granulocyte colony-stimulating factor (G-CSF). The M-CSF is secreted to stimulate hemopoietic stem cells to differentiate into macrophages or other related cell types. M-CSF appears to play a major role in promoting and maintaining reservoirs of human immunodeficiency virus type 1 (HIV-1) in infected individuals. GM-CSF is secreted by macrophages, T cells, mast cells, endothelial cells and fibroblasts. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. G-CSF is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to release the produced cells into the blood.

    Colony-Stimulating Factor (CSF) & Receptor References

      1. Haine V, et al. (2006) Macrophage colony-stimulating factor in the pathogenesis of HIV infection: potential target for therapeutic intervention. J Neuroimmune Pharmacol. 1(1):32-40.
      2. Rutella S. (2007) Granulocyte colony-stimulating factor for the induction of T-cell tolerance. Transplantation. 84(1 Suppl):S26-30.
      3. Solaroglu I, et al. (2007) Neuroprotective effect of granulocyte-colony stimulating factor. Front Biosci. 12:712-24.
      4. Hercus TR, et al. (2009) The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood. 114(7):1289-98.

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