0 products, total $0.+86-400-890-9989      Login |  Register 中文한국어

Browse By Molecule:

Your Position: Home > Cochlin Protein (COCH Protein)

Cochlin Protein (COCH Protein)

Coagulation factor C homolog, cochlin

Cochlin Products

Cochlin Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No

Cochlin

Human

Cochlin/COCH Protein, Recombinant

11368-H07H

Cochlin

Human

Cochlin/COCH (isoform short) , Recombinant Protein

11368-H07HS

Cochlin cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No

Cochlin

Human

Homo sapiens Cochlin/COCH cDNA Clone

HG11368-M

Cochlin Related Areas

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>Cochlin

Cochlin Alternative Names

Cochlin, COCH, UNQ257/PRO294, COCH-5B2, COCH5B2, DFNA9 [Homo sapiens]

Cochlin, Coch, AW122937, Coch-5B2, D12H14S564E [Mus musculus]

Cochlin Background

Cochlin, also known as COCH-5B2 and COCH, is a secreted protein which contains one LCCL domain and two VWFA domains. It is an abundant inner ear protein expressed as multiple isoforms. Its function is also unknown, but it is suspected to be an extracellular matrix component. Cochlin and type II collagen are major constituents of the inner ear extracellular matrix, and Cochlin constitutes 70% of non-collagenous protein in the inner ear, the cochlin isoforms can be classified into three subgroups, p63s, p44s and p40s. The expression of cochlin is highly specific to the inner ear. Eleven missense mutation and one in-frame deletion have been reported in the COCH gene, causing hereditary progressive sensorineural hearing loss and vestibular dysfunction, deafness autosomal dominant type 9 (DFNA9). The co-localization of cochlin and type II collagen in the fibrillar substance in the subepithelial area indicate that cochlin may play a role in the structural homeostasis of the vestibule acting in concert with the fibrillar type II collagen bundles. Defects in COCH may contribute to Meniere disease which is an autosomal dominant disorder characterized by hearing loss associated with episodic vertigo.

Cochlin Related Studies

  1. Ikezono T, et al. (2005) Expression of cochlin in the vestibular organ of rats. ORL J Otorhinolaryngol Relat Spec. 67(5): 252-8.
  2. Shindo S, et al. (2008) Spatiotemporal expression of cochlin in the inner ear of rats during postnatal development. Neurosci Lett. 444(2): 148-52.
  3. Hosokawa S, et al. (2010) Ultrastructural localization of cochlin in the rat cochlear duct. Audiol Neurootol. 15(4): 247-53.

 

Cochlin related areas, pathways, and other information

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
_×